Translating microcalcification biomarker information into the laboratory: a preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification

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dc.contributor.authorLyburn, Iain D.
dc.contributor.authorScott, Robert
dc.contributor.authorCornford, Eleanor
dc.contributor.authorBouzy, Pascaline
dc.contributor.authorStone, Nicholas
dc.contributor.authorGreenwood, Charlene
dc.contributor.authorBouybayoune, Ihsanne
dc.contributor.authorPinder, Sarah E.
dc.contributor.authorRogers, Keith
dc.date.accessioned2024-03-28T15:28:53Z
dc.date.available2024-03-28T15:28:53Z
dc.date.issued2024-03-12
dc.description.abstractThe potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to date, been limited to high brightness, synchrotron radiation sources. This study, for the first time, evaluates a laboratory-based system that interrogates histological sections containing microcalcifications. The principal objective was to determine the measurement precision of the laboratory system and assess whether this was sufficient to provide potentially clinical valuable information. Materials and methods Sections from 5 histological specimens from breast core biopsies obtained to evaluate mammographic calcification were examined using a synchrotron source and a laboratory-based instrument. The samples were chosen to represent a significant proportion of the known breast tissue, mineralogical landscape. Data were subsequently analysed using conventional methods and microcalcification characteristics such as crystallographic phase, chemical deviation from ideal stoichiometry and microstructure were determined. Results The crystallographic phase of each microcalcification (e.g., hydroxyapatite, whitlockite) was easily determined from the laboratory derived data even when a mixed phase was apparent. Lattice parameter values from the laboratory experiments agreed well with the corresponding synchrotron values and, critically, were determined to precisions that were significantly greater than required for potential clinical exploitation. Conclusion It has been shown that crystallographic characteristics of microcalcifications can be determined in the laboratory with sufficient precision to have potential clinical value. The work will thus enable exploitation acceleration of these latent microcalcification features as current dependence upon access to limited synchrotron resources is minimized.en_UK
dc.description.sponsorshipThis work was supported by a Medical Research Council research grant MR/T000406/1 that funded the conduct of the research and preparation of the article.en_UK
dc.identifier.citationLyburn ID, Scott R, Cornford E, et al., (2024) Translating microcalcification biomarker information into the laboratory: a preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification. Heliyon, Volume 10, Issue 6, March 2024, Article number e27686en_UK
dc.identifier.issn2405-8440
dc.identifier.urihttps://doi.org/10.1016/j.heliyon.2024.e27686
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/21109
dc.language.isoen_UKen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMicrocalcificationen_UK
dc.subjectX-ray scatteren_UK
dc.subjectCrystallographyen_UK
dc.subjectBiomarkeren_UK
dc.titleTranslating microcalcification biomarker information into the laboratory: a preliminary assessment utilizing core biopsies obtained from sites of mammographic calcificationen_UK
dc.typeArticleen_UK
dcterms.dateAccepted2024-03-05

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