Homoisoflavonoids are potent glucose transporter 2 (GLUT 2) inhibitors–a potential mechanism for the glucose-lowering properties of Polygonatum odoratum

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dc.contributor.authorWang, Huijun
dc.contributor.authorFowler, Mark I.
dc.contributor.authorMessenger, David J.
dc.contributor.authorTerry, Leon A.
dc.contributor.authorGu, Xuelan
dc.contributor.authorZhou, Luxian
dc.contributor.authorLiu, Ruimin
dc.contributor.authorSu, Juan
dc.contributor.authorShi, Songshan
dc.contributor.authorOrdaz-Ortiz, Jose Juan
dc.contributor.authorLian, Guoping
dc.contributor.authorBerry, Mark J.
dc.contributor.authorWang, Shunchun
dc.date.accessioned2018-03-29T08:20:29Z
dc.date.available2018-03-29T08:20:29Z
dc.date.issued2018-03-13
dc.description.abstractFoods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce. SAP homoisolflavonoids had a stronger inhibitory effect on 25 mM glucose transport (41.6 ± 2.5, 50.5 ± 7.6, 47.5 ± 1.9, 42.6 ± 2.4, and 45.7 ± 4.1% for EA-1, EA-2, EA-3, MOA, and MOB) than flavonoids (19.3 ± 2.2, 11.5 ± 3.7, 16.4 ± 2.4, 5.3 ± 1.0, 3.7 ± 2.2, and 18.1 ± 2.4% for apigenin, luteolin, quercetin, naringenin, hesperetin, and genistein) and phloretin (28.1 ± 1.6%) at 15 μM. SAP homoisoflavonoids and SGLT1 inhibitors were found to synergistically inhibit the uptake of glucose using an in vitro model comprising Caco-2 cells. This observed new mechanism of the glucose-lowering action of P. odoratum suggests that SAP homoisoflavonoids and their combination with flavonoid monoglucosides show promise as naturally functional ingredients for inclusion in foods and drinks designed to control postprandial glucose levels.en_UK
dc.identifier.citationWang H, Fowler MI, Messenger DJ, et al., (2018) Homoisoflavonoids are potent glucose transporter 2 (GLUT 2) inhibitors–a potential mechanism for the glucose-lowering properties of Polygonatum odoratum. Journal of Agricultural and Food Chemistry, Volume 66, Issue 12, 2018, pp. 3137-3145en_UK
dc.identifier.issn0021-8561
dc.identifier.urihttp://dx.doi.org/10.1021/acs.jafc.8b00107
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/13127
dc.language.isoenen_UK
dc.publisherAmerican Chemical Societyen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectglucose controlen_UK
dc.subjectGLUT2 inhibitorsen_UK
dc.subjecthomoisoflavonoidsen_UK
dc.subjectPolygonatum odoratumen_UK
dc.subjectsynergyen_UK
dc.titleHomoisoflavonoids are potent glucose transporter 2 (GLUT 2) inhibitors–a potential mechanism for the glucose-lowering properties of Polygonatum odoratumen_UK
dc.typeArticleen_UK

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