Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure

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dc.contributor.authorDiez Benavente, Ernest
dc.contributor.authorWard, Zoe
dc.contributor.authorChan, Wilson
dc.contributor.authorMohareb, Fady R.
dc.contributor.authorSutherland, Colin J.
dc.contributor.authorRoper, Cally
dc.contributor.authorCampino, Susana
dc.contributor.authorClark, Taane
dc.date.accessioned2017-05-25T14:12:36Z
dc.date.available2017-05-25T14:12:36Z
dc.date.issued2017-05-11
dc.description.abstractBackground Although Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector species, host genetics and environmental factors. Results We analysed the high-quality genomic data for 46 P. vivax isolates spanning 10 countries across 4 continents. Using population genetic methods we identified hotspots of selection pressure, including the previously reported MRP1 and DHPS genes, both putative drug resistance loci. Extra copies and deletions in the promoter region of another drug resistance candidate, MDR1 gene, and duplications in the Duffy binding protein gene (PvDBP) potentially involved in erythrocyte invasion, were also identified. For surveillance applications, continental-informative markers were found in putative drug resistance loci, and we show that organellar polymorphisms could classify P. vivax populations across continents and differentiate between Plasmodia spp. Conclusions This study has shown that genomic diversity that lies within and between P. vivax populations can be used to elucidate potential drug resistance and invasion mechanisms, as well as facilitate the molecular barcoding of the parasite for surveillance applications.en_UK
dc.identifier.citationErnest Diez Benavente, Zoe Ward, Wilson Chan, Fady R. Mohareb, Colin J. Sutherland, Cally Roper, Susana Campino and Taane G. Clark. Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. PLoS ONE Vol. 12, Iss. 5, article e0177134en_UK
dc.identifier.issn1932-6203
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0177134
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/11934
dc.language.isoenen_UK
dc.publisherPLoS Oneen_UK
dc.rightsAttribution 4.0 International (CC BY 4.0) You are free to: Share — copy and redistribute the material in any medium or format, Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Information: No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
dc.titleGenomic variation in Plasmodium vivax malaria reveals regions under selective pressureen_UK
dc.typeArticleen_UK

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