Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure

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dc.contributor.authorDiez Benavente, Ernest
dc.contributor.authorWard, Zoe
dc.contributor.authorChan, Wilson
dc.contributor.authorMohareb, Fady R.
dc.contributor.authorSutherland, Colin J.
dc.contributor.authorRoper, Cally
dc.contributor.authorCampino, Susana
dc.contributor.authorClark, Taane
dc.date.accessioned2017-05-25T14:12:36Z
dc.date.available2017-05-25T14:12:36Z
dc.date.issued2017-05-11
dc.description.abstractBackground Although Plasmodium vivax contributes to almost half of all malaria cases outside Africa, it has been relatively neglected compared to the more deadly P. falciparum. It is known that P. vivax populations possess high genetic diversity, differing geographically potentially due to different vector species, host genetics and environmental factors. Results We analysed the high-quality genomic data for 46 P. vivax isolates spanning 10 countries across 4 continents. Using population genetic methods we identified hotspots of selection pressure, including the previously reported MRP1 and DHPS genes, both putative drug resistance loci. Extra copies and deletions in the promoter region of another drug resistance candidate, MDR1 gene, and duplications in the Duffy binding protein gene (PvDBP) potentially involved in erythrocyte invasion, were also identified. For surveillance applications, continental-informative markers were found in putative drug resistance loci, and we show that organellar polymorphisms could classify P. vivax populations across continents and differentiate between Plasmodia spp. Conclusions This study has shown that genomic diversity that lies within and between P. vivax populations can be used to elucidate potential drug resistance and invasion mechanisms, as well as facilitate the molecular barcoding of the parasite for surveillance applications.en_UK
dc.identifier.citationDiez Benavente E, Ward Z, Chan W, et al., (2017) Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure. PLoS ONE, Volume 12, Issue 5, May 2017, Article number e0177134en_UK
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0177134
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/11934
dc.language.isoenen_UK
dc.publisherPLOS (Public Library of Science)en_UK
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGenomic variation in Plasmodium vivax malaria reveals regions under selective pressureen_UK
dc.typeArticleen_UK

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