Electronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infection

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dc.contributor.authorKnobloch, Henri
dc.contributor.authorSchroedl, Wieland
dc.contributor.authorTurner, Claire
dc.contributor.authorChambers, Mark
dc.contributor.authorReinhold, Petra
dc.date.accessioned2010-01-23T11:38:39Z
dc.date.available2010-01-23T11:38:39Z
dc.date.issued2010-01
dc.description.abstractThis study aimed (i) to assess the ability of electronic nose (e-nose) technology to differentiate between blood samples of experimentally infected and non-infected subjects, and (ii) to evaluate e-nose responses given by volatile organic compounds in relation to the acute phase reaction generated in the host. In an animal model of gram-negative bacterial infection (20 calves; intratracheal inoculation of Mannheimia haemolytica A1), the concentrations of the acute phase proteins (APPs; i.e. lipopolysaccharide binding protein and haptoglobin) were measured in serum samples before and after challenge, and headspaces of pre- and post-inoculation serum samples were analysed using a conducting polymer based e-nose. Significant changes of certain e-nose sensor responses allowed discrimination between samples before and after challenge. The maximal changes in responses of sensitive e-nose sensors corresponded to the peak of clinical signs. Significant correlations linked decreasing responses of multiple e-nose sensors to increasing concentrations of APPs in the peripheral blood.en_UK
dc.identifier.citationHenri Knobloch, Wieland Schroedl, Claire Turner, Mark Chambers, Petra Reinhold, Electronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infection, Sensors and Actuators B: Chemical, Volume 144, Issue 1, 29 January 2010, Pages 81-87en_UK
dc.identifier.issn0925-4005
dc.identifier.urihttp://dx.doi.org/10.1016/j.snb.2009.10.034.
dc.identifier.urihttp://hdl.handle.net/1826/4178
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.subjectelectronic noseen_UK
dc.subjectacute phase proteins (APP),en_UK
dc.subjectanimal modelen_UK
dc.subjectgram-negative bacterialen_UK
dc.subjectMannheimia haemolytica A1en_UK
dc.subjecthost responseen_UK
dc.titleElectronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infectionen_UK
dc.typeArticleen_UK

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