Soft and flexible material-based affinity sensors

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dc.contributor.authorMeng, Lingyin
dc.contributor.authorTurner, Anthony P. F.
dc.contributor.authorMak, Wing Cheung
dc.date.accessioned2020-11-09T14:05:40Z
dc.date.available2020-11-09T14:05:40Z
dc.date.issued2019-05-06
dc.description.abstractRecent advances in biosensors and point-of-care (PoC) devices are poised to change and expand the delivery of diagnostics from conventional lateral-flow assays and test strips that dominate the market currently, to newly emerging wearable and implantable devices that can provide continuous monitoring. Soft and flexible materials are playing a key role in propelling these trends towards real-time and remote health monitoring. Affinity biosensors have the capability to provide for diagnosis and monitoring of cancerous, cardiovascular, infectious and genetic diseases by the detection of biomarkers using affinity interactions. This review tracks the evolution of affinity sensors from conventional lateral-flow test strips to wearable/implantable devices enabled by soft and flexible materials. Initially, we highlight conventional affinity sensors exploiting membrane and paper materials which have been so successfully applied in point-of-care tests, such as lateral-flow immunoassay strips and emerging microfluidic paper-based devices. We then turn our attention to the multifarious polymer designs that provide both the base materials for sensor designs, such as PDMS, and more advanced functionalised materials that are capable of both recognition and transduction, such as conducting and molecularly imprinted polymers. The subsequent content discusses wearable soft and flexible material-based affinity sensors, classified as flexible and skin-mountable, textile materials-based and contact lens-based affinity sensors. In the final sections, we explore the possibilities for implantable/injectable soft and flexible material-based affinity sensors, including hydrogels, microencapsulated sensors and optical fibers. This area is truly a work in progress and we trust that this review will help pull together the many technological streams that are contributing to the field.en_UK
dc.identifier.citationMeng L, Turner APF, Mak WC. (2019) Soft and flexible material-based affinity sensors. Biotechnology Advances, Volume 39, March-April 2019, Article number 107398en_UK
dc.identifier.issn0734-9750
dc.identifier.urihttps://doi.org/10.1016/j.biotechadv.2019.05.004
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/15977
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAffinity sensorsen_UK
dc.subjectPoint-of-careen_UK
dc.subjectWearableen_UK
dc.subjectImplantableen_UK
dc.subjectPapersen_UK
dc.subjectConducting polymersen_UK
dc.subjectMolecular imprinted polymersen_UK
dc.subjectSkin patchesen_UK
dc.subjectContact lensesen_UK
dc.subjectHydrogelsen_UK
dc.titleSoft and flexible material-based affinity sensorsen_UK
dc.typeArticleen_UK

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