Supercritical fluid coating of API on excipient enhances drug release

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dc.contributor.authorLi, Qingguo
dc.contributor.authorHuang, Deen
dc.contributor.authorLu, Tiejun
dc.contributor.authorSeville, Jonathan P. K.
dc.contributor.authorXing, Lei
dc.contributor.authorLeeke, Gary A.
dc.date.accessioned2017-01-05T11:24:30Z
dc.date.available2017-01-05T11:24:30Z
dc.date.issued2016-12-18
dc.description.abstractA process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the model API to coat onto MCC. A number of operational parameters of the process were investigated: fluidization velocity, coating pressure, temperature, concentration of drug solution, drug solution flow rate, drug mass, organic solvent, MCC mass and size and CO2-to-organic solution ratio. SEM and SPM analyses showed that the MCC particle surfaces were covered with near-spherical nanoparticles with a diameter of approximately 100–200 nm, substantially smaller than the as-received API material. XRD showed that naringin changed from crystalline to amorphous during processing. The coated particles resulting from the SAS fluidized bed process have a higher loading of API, gave faster release rates and higher release ratios in comparison with those produced using a conventional fluidized bed coating process. The approach could be transferred to other industries where release is important such as agrochemical, cosmetic and food.en_UK
dc.identifier.citationLi Q, Huang D, Lu T, Seville JPK, Xing L, Leeke GA, Supercritical fluid coating of API on excipient enhances drug release. Chemical Engineering Journal, Volume 313, 1 April 2017, pp. 317-327en_UK
dc.identifier.issn1385-8947
dc.identifier.urihttp://dx.doi.org/10.1016/j.cej.2016.12.066
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/11216
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSupercritical Anti-Solventen_UK
dc.subjectFluidized bed coatingen_UK
dc.subjectNaringinen_UK
dc.subjectRelease profileen_UK
dc.subjectNanoparticlesen_UK
dc.titleSupercritical fluid coating of API on excipient enhances drug releaseen_UK
dc.typeArticleen_UK

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