Thermally dynamic examination of local order in nanocrystalline hydroxyapatite

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dc.contributor.authorArnold, Emily
dc.contributor.authorGosling, Sarah
dc.contributor.authorDavies, Samantha K.
dc.contributor.authorCross, Hannah L.
dc.contributor.authorEvans, Paul
dc.contributor.authorKeeble, Dean S.
dc.contributor.authorGreenwood, Charlene
dc.contributor.authorRogers, Keith D.
dc.date.accessioned2022-09-07T09:20:01Z
dc.date.available2022-09-07T09:20:01Z
dc.date.issued2022-08-13
dc.description.abstractThe main mineral component of bone is hydroxyapatite, a commonly nanocrystalline material which presents many challenges for those trying to characterize it. Here, local structure is analyzed using X-ray total scattering for synthetic samples, to enable a better understanding of the nanocrystalline nature of hydroxyapatite. Two samples were measured dynamically during heat treatment from 25°C to 800°C, and were analyzed using small box modelling. Analysis of sequential measurements when dwelling at key temperatures showed a significant relationship between time and temperature, indicating a process occurring more slowly than thermal expansion. This indicates a decrease in B-type CO32- substitution between 550°C and 575°C and an increase in A-type CO32- substitution above 750°C. A greater understanding of local, intermediate, and long-range order of this complex biomineral during heat treatment can be of interest in several sectors, such as in forensic, biomedical and clinical settings for the study of implant coatings and bone diseases including osteoporosis and osteoarthritis.en_UK
dc.description.sponsorshipEngineering and Physical Sciences Research Council (EPSRC): EP/T034238/1. This work was also partly supported by a Royal Society and Wolfson Foundation (RSWF/R1/180012). This work was carried out with the support of the Diamond Light Source, instrument I15-1 (proposal cy24283).en_UK
dc.identifier.citationArnold EL, Gosling S, Davies SK, et al., (2022) Thermally dynamic examination of local order in nanocrystalline hydroxyapatite, Journal of Solid State Chemistry, Volume 315, November 2022, Article number 123474en_UK
dc.identifier.eissn1095-726X
dc.identifier.issn0022-4596
dc.identifier.urihttps://doi.org/10.1016/j.jssc.2022.123474
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18417
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHydroxyapatiteen_UK
dc.subjectPowder X-ray Diffraction (PXRD)en_UK
dc.subjectTotal Scatteringen_UK
dc.subjectPair Distribution Function (PDF)en_UK
dc.titleThermally dynamic examination of local order in nanocrystalline hydroxyapatiteen_UK
dc.typeArticleen_UK

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