Characterisation of the transcriptional potential of intergenic CCG-repeats

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dc.contributor.advisorJones, Christopher
dc.contributor.authorCozens, Jacob
dc.date.accessioned2024-03-06T16:45:21Z
dc.date.available2024-03-06T16:45:21Z
dc.date.issued2011-08
dc.description.abstractCCG repeats have been found to have a non random distribution throughout the human genome. Previous analysis of ChIP-seq data from 800 intergenic CCG-repeats shows that they are associated with RNA polymerase II and several histone modifications that characterise transcription initiation including H3K4me3. RNA polymerase II, H3K4me3 and nucleosome distribution profiles have been analysed at these repeat regions using computer programming techniques. These profiles have in part been found to be similar to those observed at transcription start sites and so this raises the potential for CCG repeats to be implicated as alternative sites for transcription initiation.en_UK
dc.description.coursenameApplied Bioinformaticsen_UK
dc.description.sponsorshipBiotechnology and Biological (BBSRC)en_UK
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/20939
dc.language.isoenen_UK
dc.publisherCranfield Universityen_UK
dc.publisher.departmentSASen_UK
dc.subjecthuman genomeen_UK
dc.subjectRNA polymeraseen_UK
dc.subjectnucleosome distribution profilesen_UK
dc.subjectCCG repeatsen_UK
dc.subjectChIP-seq dataen_UK
dc.titleCharacterisation of the transcriptional potential of intergenic CCG-repeatsen_UK
dc.typeThesis or dissertationen_UK
dc.type.qualificationlevelMastersen_UK
dc.type.qualificationnameMScen_UK

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