Ant-behavior inspired intelligent nanonet for targeted drug delivery in cancer therapy

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dc.contributor.authorLin, Lin
dc.contributor.authorHuang, Fupeng
dc.contributor.authorYan, Hao
dc.contributor.authorLiu, Fuqiang
dc.contributor.authorGuo, Weisi
dc.date.accessioned2020-09-08T10:05:02Z
dc.date.available2020-09-08T10:05:02Z
dc.date.issued2020-04-01
dc.description.abstractTargeted drug delivery system is believed as one of the most promising solutions for cancer treatment due to its low-dose requirement and less side effects. However, both passive targeting and active targeting rely on systemic blood circulation and diffusion, which is actually not the real “active” drug delivery. In this paper, an ant-behavior inspired nanonetwork composing of intelligent nanomachines is proposed. A big intelligent nanomachine take small intelligent nanomachines and drugs to the vicinity of of the tumor area. The small intelligent nanomachines can coordinate with each other to find the most effective path to the tumor cell for drug transportation. The framework and mechanism of this cooperative network are proposed. The route finding algorithm is presented. The convergence performance is analytically analyzed where the influence of the factors such as molecule degradation rate, home-destination distance, number of small nanomachines to the convergence is presented. Finally the simulation results validate the effectiveness of the proposed mechanism and analytical analysisen_UK
dc.identifier.citationLin L, Huang F, Yan H, et al., (2020) Ant-behavior inspired intelligent nanonet for targeted drug delivery in cancer therapy. IEEE Transactions on NanoBioscience, Volume 19, Issue 3, July 2020, pp. 323-332en_UK
dc.identifier.issn1536-1241
dc.identifier.urihttps://doi.org/10.1109/TNB.2020.2984940
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/15768
dc.language.isoenen_UK
dc.publisherIEEEen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectcancer therapyen_UK
dc.subjecttargeted drug deliveryen_UK
dc.subjectmolecular communicationen_UK
dc.subjectNanoNeten_UK
dc.subjectAnten_UK
dc.titleAnt-behavior inspired intelligent nanonet for targeted drug delivery in cancer therapyen_UK
dc.typeArticleen_UK

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