Optical investigation of three-dimensional human skin equivalents: a pilot study

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dc.contributor.authorKallepalli, Akhil
dc.contributor.authorMcCall, Blake
dc.contributor.authorJames, David B.
dc.contributor.authorJunaid, Sarah
dc.contributor.authorHalls, James
dc.contributor.authorRichardson, Mark A.
dc.date.accessioned2019-10-11T13:59:02Z
dc.date.available2019-10-11T13:59:02Z
dc.date.issued2019-10-08
dc.description.abstractHuman skin equivalents (HSEs) are three‐dimensional living models of human skin that are prepared in vitro by seeding cells onto an appropriate scaffold. They recreate the structure and biological behaviour of real skin, allowing the investigation of processes such as keratinocyte differentiation and interactions between the dermal and epidermal layers. However, for wider applications, their optical and mechanical properties should also replicate those of real skin. We therefore conducted a pilot study to investigate the optical properties of HSEs. We compared Monte Carlo simulations of (1) real human skin and (2) two‐layer optical models of HSEs with (3) experimental measurements of transmittance through HSE samples. The skin layers were described using a hybrid collection of optical attenuation coefficients. A linear relationship was observed between the simulations and experiments. For samples thinner than 0.5 mm, an exponential increase in detected power was observed due to fewer instances of absorption and scattering.en_UK
dc.identifier.citationKallepalli A, McCall B, James DB, et al., (2020) Optical investigation of three-dimensional human skin equivalents: a pilot study. Journal of Biophotonics, Volume 13, Issue 1, January 2020, Article number e20190053.en_UK
dc.identifier.cris24562835
dc.identifier.issn1864-063X
dc.identifier.urihttps://doi.org/10.1002/jbio.201960053
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/14609
dc.language.isoenen_UK
dc.publisherWiley-VCH Verlagen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjecttissue engineeringen_UK
dc.subjectlasersen_UK
dc.subjectTraceProen_UK
dc.subjectMonte Carloen_UK
dc.titleOptical investigation of three-dimensional human skin equivalents: a pilot studyen_UK
dc.typeArticleen_UK

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