Fermentative valorisation of xylose-rich hemicellulosic hydrolysates from agricultural waste residues for lactic acid production under non-sterile conditions

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dc.contributor.authorCox, Rylan
dc.contributor.authorNarisetty, Vivek
dc.contributor.authorCastro, Eulogio
dc.contributor.authorAgrawal, Deepti
dc.contributor.authorJacob, Samuel
dc.contributor.authorKumar, Gopalakrishnan
dc.contributor.authorKumar, Deepak
dc.contributor.authorKumar, Vinod
dc.date.accessioned2023-06-15T11:43:46Z
dc.date.available2023-06-15T11:43:46Z
dc.date.issued2023-05-18
dc.description.abstractLactic acid (LA) is a platform chemical with diverse industrial applications. Presently, commercial production of LA is dominated by microbial fermentation using sugary or starch-based feedstocks. Research pursuits emphasizing towards sustainable production of LA using non-edible and renewable feedstocks have accelerated the use of lignocellulosic biomass (LCB). The present study focuses on the valorisation of xylose derived from sugarcane bagasse (SCB) and olive pits (OP) through hydrothermal and dilute acid pretreatment, respectively. The xylose-rich hydrolysate obtained was used for LA production by homo-fermentative and thermophilic Bacillus coagulans DSM2314 strain under non-sterile conditions. The fed-batch mode of fermentation resulted in maximum LA titers of 97.8, 52.4 and 61.3 g/L with a yield of 0.77, 0.66 and 0.71 g/g using pure xylose, xylose-rich SCB and OP hydrolysates, respectively. Further, a two-step aqueous two-phase system (ATPS) extraction technique was employed for the separation and recovery of LA accumulated on pure and crude xylose. The LA recovery was 45 – 65% in the first step and enhanced to 80–90% in the second step.The study demonstrated an efficient integrated biorefinery approach to valorising the xylose-rich stream for cost-effective LA production and recovery.en_UK
dc.description.sponsorshipBiotechnology and Biological Sciences Research Council (BBSRC): BB/S011951/1. Engineering and Physical Sciences Research Council (EPSRC): EP/L016389/1. Innovate UK. Department of Biotechnology, Indiaen_UK
dc.identifier.citationCox R, Narisetty V, Castro E, et al., (2023) Fermentative valorisation of xylose-rich hemicellulosic hydrolysates from agricultural waste residues for lactic acid production under non-sterile conditions, Waste Management, Volume 166, July 2023, pp. 336-345en_UK
dc.identifier.eissn1879-2456
dc.identifier.issn0956-053X
dc.identifier.urihttps://doi.org/10.1016/j.wasman.2023.05.015
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/19782
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLactic aciden_UK
dc.subjectBacillus coagulansen_UK
dc.subjectOlive pitsen_UK
dc.subjectSugarcane bagasseen_UK
dc.subjectNon-sterile conditionsen_UK
dc.subjectXylose-rich hydrolysateen_UK
dc.titleFermentative valorisation of xylose-rich hemicellulosic hydrolysates from agricultural waste residues for lactic acid production under non-sterile conditionsen_UK
dc.typeArticleen_UK

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