Nanoindentation response of 3D printed PEGDA hydrogels in hydrated environment

Simple item page
dc.contributor.authorHakim Khalili, Mohammad
dc.contributor.authorWilliams, Craig J.
dc.contributor.authorMicallef, Christian
dc.contributor.authorDuarte-Martinez, Fabian
dc.contributor.authorAfsar, Ashfaq
dc.contributor.authorZhang, Rujing
dc.contributor.authorWilson, Sandra
dc.contributor.authorDossi, Eleftheria
dc.contributor.authorImpey, Susan A.
dc.contributor.authorGoel, Saurav
dc.contributor.authorAria, Adrianus Indrat
dc.date.accessioned2023-02-01T12:13:42Z
dc.date.available2023-02-01T12:13:42Z
dc.date.issued2023-01-20
dc.description.abstractHydrogels are commonly used materials in tissue engineering and organ-on-chip devices. This study investigated the nanomechanical properties of monolithic and multilayered poly(ethylene glycol) diacrylate (PEGDA) hydrogels manufactured using bulk polymerization and layer-by-layer projection lithography processes, respectively. An increase in the number of layers (or reduction in layer thickness) from 1 to 8 and further to 60 results in a reduction in the elastic modulus from 5.53 to 1.69 and further to 0.67 MPa, respectively. It was found that a decrease in the number of layers induces a lower creep index (CIT) in three-dimensional (3D) printed PEGDA hydrogels. This reduction is attributed to mesoscale imperfections that appear as pockets of voids at the interfaces of the multilayered hydrogels attributed to localized regions of unreacted prepolymers, resulting in variations in defect density in the samples examined. An increase in the degree of cross-linking introduced by a higher dosage of ultraviolet (UV) exposure leads to a higher elastic modulus. This implies that the elastic modulus and creep behavior of hydrogels are governed and influenced by the degree of cross-linking and defect density of the layers and interfaces. These findings can guide an optimal manufacturing pathway to obtain the desirable nanomechanical properties in 3D printed PEGDA hydrogels, critical for the performance of living cells and tissues, which can be engineered through control of the fabrication parameters.en_UK
dc.identifier.citationKhalili MH, Williams CJ, Micallef C, et al., (2023) Nanoindentation response of 3D printed PEGDA hydrogels in hydrated environment. ACS Applied Polymer Materials, Volume 5, Issue 2, 10 February 2023, pp. 1180–1190en_UK
dc.identifier.issn2637-6105
dc.identifier.urihttps://doi.org/10.1021/acsapm.2c01700
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/19076
dc.language.isoenen_UK
dc.publisherAmerican Chemical Societyen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectpoly(ethylene glycol) diacrylateen_UK
dc.subjectnanoindentationen_UK
dc.subject3D printingen_UK
dc.subjectcross-linked hydrogelsen_UK
dc.subjectcreep behavioren_UK
dc.titleNanoindentation response of 3D printed PEGDA hydrogels in hydrated environmenten_UK
dc.typeArticleen_UK

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nanoindentation_response_of_3D_printed-2023.pdf
Size:
7.88 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Staff publications (SATM)