Use of the analysis of the volatile faecal metabolome in screening for colorectal cancer

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dc.contributor.authorBatty, Claire A.
dc.contributor.authorCauchi, Michael
dc.contributor.authorLourenço, Célia
dc.contributor.authorHunter, John O.
dc.contributor.authorTurner, Claire
dc.date.accessioned2016-03-08T14:13:43Z
dc.date.available2016-03-08T14:13:43Z
dc.date.issued2015-06-18
dc.description.abstractDiagnosis of colorectal cancer is an invasive and expensive colonoscopy, which is usually carried out after a positive screening test. Unfortunately, existing screening tests lack specificity and sensitivity, hence many unnecessary colonoscopies are performed. Here we report on a potential new screening test for colorectal cancer based on the analysis of volatile organic compounds (VOCs) in the headspace of faecal samples. Faecal samples were obtained from subjects who had a positive faecal occult blood sample (FOBT). Subjects subsequently had colonoscopies performed to classify them into low risk (non-cancer) and high risk (colorectal cancer) groups. Volatile organic compounds were analysed by selected ion flow tube mass spectrometry (SIFT-MS) and then data were analysed using both univariate and multivariate statistical methods. Ions most likely from hydrogen sulphide, dimethyl sulphide and dimethyl disulphide are statistically significantly higher in samples from high risk rather than low risk subjects. Results using multivariate methods show that the test gives a correct classification of 75% with 78% specificity and 72% sensitivity on FOBT positive samples, offering a potentially effective alternative to FOBT.en_UK
dc.identifier.citationBatty CA, Cauchi M, Lourenço C, Hunter JO, Turner C (2015) Use of the Analysis of the Volatile Faecal Metabolome in Screening for Colorectal Cancer. PLoS ONE Vol.10(6), e0130301en_UK
dc.identifier.issn1932-6203
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0130301
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/9753
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Attribution 4.0 International (CC BY 4.0) You are free to: Share — copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms. Under the following terms: Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Information: No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.en_UK
dc.titleUse of the analysis of the volatile faecal metabolome in screening for colorectal canceren_UK
dc.typeArticleen_UK

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