Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures

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dc.contributor.authorBonicelli, Andrea
dc.contributor.authorTay, Tabitha
dc.contributor.authorCobb, Justin P.
dc.contributor.authorBoughton, Oliver R.
dc.contributor.authorHansen, Ulrich
dc.date.accessioned2022-12-14T14:11:57Z
dc.date.available2022-12-14T14:11:57Z
dc.date.issued2022-12-14
dc.description.abstractMeasurement of the properties of bone as a material can happen in various length scales in its hierarchical and composite structure. The aim of this study was to test the tissue level properties of clinically-relevant human bone samples which were collected from donors belonging to three groups: ageing donors who suffered no fractures (Control); untreated fracture patients (Fx-Untreated) and patient who experienced hip fracture despite being treated with bisphosphonates (Fx-BisTreated). Tissue level properties were assessed by (a) nanoindentation and (b) synchrotron tensile tests (STT) where strains were measured at the ‘tissue’, ‘fibril’ and ‘mineral’ levels by using simultaneous Wide-angle - (WAXD) and Small angle- X-ray diffraction (SAXD). The composition was analysed by thermogravimetric analysis and material level endo- and exo-thermic reactions by differential scanning calorimetry (TGA/DSC3+). Irrespective of treatment fracture donors exhibited significantly lower tissue, fibril and mineral strain at the micro and nanoscale respectively and had a higher mineral content than controls. In nanoindentation only nanohardness was significantly greater for Controls and Fx-BisTreated versus Fx-Untreated. The other nanoindentation parameters did not vary significantly across the three groups. There was a highly significant positive correlation (p < 0.001) between organic content and tissue level strain behaviour. Overall hip-fractures were associated with lower STT nanostrains and it was behaviour measured by STT which proved to be a more effective approach for predicting fracture risk because evidently it was able to demonstrate the mechanical deficit for the bone tissue of the donors who had experienced fractures.en_UK
dc.identifier.citationBonicelli A, Tay T, Cobb JP, et al., (2023) Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures. Journal of the Mechanical Behavior of Biomedical Materials, Volume 138, February 2023, Article number 105573en_UK
dc.identifier.issn1751-6161
dc.identifier.urihttps://doi.org/10.1016/j.jmbbm.2022.105573
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18818
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBone propertiesen_UK
dc.subjectSynchrotronen_UK
dc.subjectNanoindentationen_UK
dc.subjectFractureen_UK
dc.subjectAgeingen_UK
dc.titleAssociation between nanoscale strains and tissue level nanoindentation properties in age-related hip-fracturesen_UK
dc.typeArticleen_UK

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