Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms

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dc.contributor.authorHans, Shriya
dc.contributor.authorKumar, Nilesh
dc.contributor.authorGohil, Nisarg
dc.contributor.authorKhambhati, Khushal
dc.contributor.authorBhattacharjee, Gargi
dc.contributor.authorDeb, Shalini S.
dc.contributor.authorMaurya, Rupesh
dc.contributor.authorKumar, Vinod
dc.contributor.authorReshamwala, Shamlan M. S.
dc.contributor.authorSingh, Vijai
dc.date.accessioned2022-06-13T14:06:26Z
dc.date.available2022-06-13T14:06:26Z
dc.date.issued2022-05-28
dc.description.abstractThe surging demand of value-added products has steered the transition of laboratory microbes to microbial cell factories (MCFs) for facilitating production of large quantities of important native and non-native biomolecules. This shift has been possible through rewiring and optimizing different biosynthetic pathways in microbes by exercising frameworks of metabolic engineering and synthetic biology principles. Advances in genome and metabolic engineering have provided a fillip to create novel biomolecules and produce non-natural molecules with multitude of applications. To this end, numerous MCFs have been developed and employed for production of non-natural nucleic acids, proteins and different metabolites to meet various therapeutic, biotechnological and industrial applications. The present review describes recent advances in production of non-natural amino acids, nucleic acids, biofuel candidates and platform chemicals.en_UK
dc.identifier.citationHans S, Kumar N, Gohil N, et al., (2022) Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms. Microbial Cell Factories, Volume 21, Issue 1, Article number 100en_UK
dc.identifier.issn1475-2859
dc.identifier.urihttps://doi.org/10.1186/s12934-022-01828-y
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/18013
dc.language.isoenen_UK
dc.publisherBMC (Part of Springer Nature)en_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMicrobial cell factoriesen_UK
dc.subjectMetabolic engineeringen_UK
dc.subjectNon-canonical amino acidsen_UK
dc.subjectXeno nucleic acidsen_UK
dc.subjectBiofuelsen_UK
dc.subjectNon-natural biomoleculesen_UK
dc.titleRebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganismsen_UK
dc.typeArticleen_UK

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