Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms
dc.contributor.author | Hans, Shriya | |
dc.contributor.author | Kumar, Nilesh | |
dc.contributor.author | Gohil, Nisarg | |
dc.contributor.author | Khambhati, Khushal | |
dc.contributor.author | Bhattacharjee, Gargi | |
dc.contributor.author | Deb, Shalini S. | |
dc.contributor.author | Maurya, Rupesh | |
dc.contributor.author | Kumar, Vinod | |
dc.contributor.author | Reshamwala, Shamlan M. S. | |
dc.contributor.author | Singh, Vijai | |
dc.date.accessioned | 2022-06-13T14:06:26Z | |
dc.date.available | 2022-06-13T14:06:26Z | |
dc.date.issued | 2022-05-28 | |
dc.description.abstract | The surging demand of value-added products has steered the transition of laboratory microbes to microbial cell factories (MCFs) for facilitating production of large quantities of important native and non-native biomolecules. This shift has been possible through rewiring and optimizing different biosynthetic pathways in microbes by exercising frameworks of metabolic engineering and synthetic biology principles. Advances in genome and metabolic engineering have provided a fillip to create novel biomolecules and produce non-natural molecules with multitude of applications. To this end, numerous MCFs have been developed and employed for production of non-natural nucleic acids, proteins and different metabolites to meet various therapeutic, biotechnological and industrial applications. The present review describes recent advances in production of non-natural amino acids, nucleic acids, biofuel candidates and platform chemicals. | en_UK |
dc.identifier.citation | Hans S, Kumar N, Gohil N, et al., (2022) Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms. Microbial Cell Factories, Volume 21, Issue 1, Article number 100 | en_UK |
dc.identifier.issn | 1475-2859 | |
dc.identifier.uri | https://doi.org/10.1186/s12934-022-01828-y | |
dc.identifier.uri | http://dspace.lib.cranfield.ac.uk/handle/1826/18013 | |
dc.language.iso | en | en_UK |
dc.publisher | BMC (Part of Springer Nature) | en_UK |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Microbial cell factories | en_UK |
dc.subject | Metabolic engineering | en_UK |
dc.subject | Non-canonical amino acids | en_UK |
dc.subject | Xeno nucleic acids | en_UK |
dc.subject | Biofuels | en_UK |
dc.subject | Non-natural biomolecules | en_UK |
dc.title | Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms | en_UK |
dc.type | Article | en_UK |