Fast emitting nanocomposites for high-resolution ToF-PET imaging based on multicomponent scintillators

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dc.contributor.authorOrfano, Matteo
dc.contributor.authorPagano, Fiammetta
dc.contributor.authorMattei, Ilaria
dc.contributor.authorCova, Francesca
dc.contributor.authorSecchi, Valeria
dc.contributor.authorBracco, Silvia
dc.contributor.authorRogers, Edith
dc.contributor.authorBarbieri, Luca
dc.contributor.authorLorenzi, Roberto
dc.contributor.authorBizarri, Gregory
dc.contributor.authorAuffray, Etiennette
dc.contributor.authorMonguzzi, Angelo
dc.date.accessioned2024-05-01T14:59:42Z
dc.date.available2024-05-01T14:59:42Z
dc.date.issued2024-02-28
dc.description.abstractTime-of-Flight Positron Emission Tomography (ToF-PET) is a medical imaging technique, based on the detection of two back-to-back γ-photons generated from radiotracers injected into the body. Its limit is the ability of employed scintillation detectors to discriminate in time the arrival of γ-pairs, that is, the coincidence time resolution (CTR). A CTR < 50 ps will enable fast imaging with ultralow radiotracer dose. Monolithic materials do not have simultaneously the required high light output and fast emission characteristics, thus the concept of scintillating heterostructure is proposed, where the device is made of a dense scintillator coupled to a fast-emitting light material. Here a composite polymeric scintillator loaded with hafnium oxide nanoparticles is presented. This enhanced by +300% its scintillation yield, by surpassing commercial plastic scintillators. The nanocomposite is coupled to bismuth germanate oxide (BGO) realizing a multilayer metascintillator. The energy sharing between its components is observed, which activates the nanocomposite's fast emission enabling a net CTR improvement of 25% with respect to monolithic BGO. These results demonstrate that a controlled loading with dense nanomaterials is an excellent strategy to enhance the performance of polymeric scintillators for their use in advanced radiation detection and imaging technologies.en_UK
dc.description.sponsorship: We acknowledge support from the European Community through the grant no. 899293, HORIZON 2020 - SPARTE FET OPEN. Financial support from the Italian Ministry of University (MUR) through grant no. PRIN 2020—SHERPA no. H45F2100343000. CERN knowledge transfer for medical applications budget. Cranfield University, acknowledges that part of this research was funded by the UK Engineering and Physical Sciences Research Council (EPSRC) grant EP/S013652/1.en_UK
dc.identifier.citationOrfano M, Pagano F, Mattei I, et al., (2024) Fast Emitting Nanocomposites for High‐Resolution ToF‐PET Imaging Based on Multicomponent Scintillators. Advanced Materials Technologies, Volume 9, Issue 10, May 2024, Article number 2302075en_UK
dc.identifier.eissn2365-709X
dc.identifier.issn2365-709X
dc.identifier.urihttps://doi.org/10.1002/admt.202302075
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/21300
dc.language.isoen_UKen_UK
dc.publisherWileyen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectconjugated chromophoresen_UK
dc.subjectenergy sharingen_UK
dc.subjectmulticomponent scintillatorsen_UK
dc.subjectnanocompositesen_UK
dc.subjectoptical deviceen_UK
dc.subjectscintillationen_UK
dc.subjectToF-PETen_UK
dc.titleFast emitting nanocomposites for high-resolution ToF-PET imaging based on multicomponent scintillatorsen_UK
dc.typeArticleen_UK
dcterms.dateAccepted2024-02-12

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