Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics

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dc.contributor.authorShakeri, Shahryar
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorRoghanian, Rasoul
dc.contributor.authorAfshar, Elham Ghasemipour
dc.contributor.authorPardakhty, Abbas
dc.contributor.authorMohammadinejad, Reza
dc.contributor.authorKumar, Anuj
dc.contributor.authorThakur, Vijay Kumar
dc.date.accessioned2020-02-21T16:48:55Z
dc.date.available2020-02-21T16:48:55Z
dc.date.issued2020-01-13
dc.description.abstractThe blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.en_UK
dc.identifier.citationShakeri S, Ashrafizadeh M, Zarrabi A, et al., (2020) Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics. Biomedicines, Volume 8, Issue 1, January 2020, Article number 13en_UK
dc.identifier.issn2227-9059
dc.identifier.urihttps://doi.org/10.3390/biomedicines8010013
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/15171
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectblood–brain barrier (BBB)en_UK
dc.subjectcentral nervous system (CNS)en_UK
dc.subjectnanotechnologyen_UK
dc.subjectdrug delivery systemsen_UK
dc.subjectpolymeric nanoparticlesen_UK
dc.subjecttheranosticsen_UK
dc.titleMultifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranosticsen_UK
dc.typeArticleen_UK

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