Targeted enrichment of nucleic acid bionic arms enhances the hydrolysis activity of nanozymes for degradation and real-time monitoring of organophosphorus pesticides in water

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dc.contributor.authorZhou, Jialong
dc.contributor.authorXiong, Dinghui
dc.contributor.authorZhang, Hu
dc.contributor.authorXiao, Jiaxuan
dc.contributor.authorHuang, Rui
dc.contributor.authorQiao, Ze
dc.contributor.authorYang, Zhugen
dc.contributor.authorZhang, Zhen
dc.date.accessioned2025-03-13T12:31:17Z
dc.date.available2025-03-13T12:31:17Z
dc.date.freetoread2025-03-13
dc.date.issued2025-01-28
dc.date.pubOnline2025-01-15
dc.description.abstractOrganophosphorus pesticides (OPs) pose significant environmental and health risks, and their detoxification through catalytic hydrolysis using zirconium-based metal-organic frameworks (Zr-MOFs) has attracted considerable interest due to the strong Lewis acid metal ions. Albeit important, the defects of the materials for OP hydrolysis (e.g., poor degradation efficiency, rate, and selectivity) limit their further application. Herein, a nucleic acid bionic arm-modified biomimetic nanozyme (MOF-808-Apt) was designed through a Zr-MOF and a specific aptamer against OPs, which was employed for the efficient and selective degradation of OPs. At the system, the functionalized biomimetic nanozyme can continuously capture trace OPs onto its catalytic sites for degradation with the fabricated nucleic acid bionic arms, significantly improving their catalytic activities compared to bare MOF-808 using paraoxon as a model of OPs, providing better performances including (i) an excellent degradation efficiency, boosting from 4 to over 60% within 6 min; (ii) a satisfactory catalytic rate (the pseudo-first-order rate constants of paraoxon hydrolysis improved from 0.09 to 0.14 min-1); and (iii) good selective degradation because of aptamers used. Besides, this dynamic degradation process could be visually recorded in real time with high sensitivity (limit of detection, 0.18 μM) because of the obvious color change of the reaction solution and signal amplification ascribed to increasing local concentrations of targets by the nucleic acid bionic arms. Summarily, this work provides a new strategy for the effective and selective degradation of typical OPs and concurrent monitoring of their dynamic degradation process.
dc.description.journalNameEnvironmental Science & Technology
dc.description.sponsorshipLeverhulme Trust, National Natural Science Foundation of China, Natural Environment Research Council
dc.description.sponsorshipThis work was supported by the National Natural Science Foundation of China (Grant Nos. 22176075 and 22476072)and the Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment. Besides, Z.Y. also thanks the Leverhulme Trust Research Leadership Awards (RL-2022-041) and the UKRI NERC Fellowship grant (NE/R013349/2).
dc.format.extentpp. 1844-1853
dc.format.mediumPrint-Electronic
dc.identifier.citationZhou J, Xiong D, Zhang H, et al., (2025) Targeted enrichment of nucleic acid bionic arms enhances the hydrolysis activity of nanozymes for degradation and real-time monitoring of organophosphorus pesticides in water. Environmental Science & Technology, Volume 59, Issue 3, January 2025, pp. 1844-1853en_UK
dc.identifier.eissn1520-5851
dc.identifier.elementsID562413
dc.identifier.issn0013-936X
dc.identifier.issueNo3
dc.identifier.urihttps://doi.org/10.1021/acs.est.4c13849
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23605
dc.identifier.volumeNo59
dc.languageEnglish
dc.language.isoen
dc.publisherAmerican Chemical Societyen_UK
dc.publisher.urihttps://pubs.acs.org/doi/10.1021/acs.est.4c13849
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectmetal-organic frameworken_UK
dc.subjectnanozymeen_UK
dc.subjectsignal amplificationen_UK
dc.subjectrapid detectionen_UK
dc.subjectorganophosphorus pesticidesen_UK
dc.subject4105 Pollution and Contaminationen_UK
dc.subject34 Chemical Sciencesen_UK
dc.subjectBiotechnologyen_UK
dc.subjectEnvironmental Sciencesen_UK
dc.subject.meshPesticidesen_UK
dc.subject.meshHydrolysisen_UK
dc.subject.meshOrganophosphorus Compoundsen_UK
dc.subject.meshNucleic Acidsen_UK
dc.subject.meshWater Pollutants, Chemicalen_UK
dc.subject.meshMetal-Organic Frameworksen_UK
dc.subject.meshZirconiumen_UK
dc.titleTargeted enrichment of nucleic acid bionic arms enhances the hydrolysis activity of nanozymes for degradation and real-time monitoring of organophosphorus pesticides in wateren_UK
dc.typeArticle
dc.type.subtypeJournal Article
dcterms.dateAccepted2025-01-10

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