Inhibition of the intestinal postprandial glucose transport by gallic acid and gallic acid derivatives

Simple item page
dc.contributor.authorWang, Huijun
dc.contributor.authorFowler, Mark I.
dc.contributor.authorMessenger, David J.
dc.contributor.authorOrdaz-Ortiz, Jose Juan
dc.contributor.authorGu, Xuelan
dc.contributor.authorShi, Songshan
dc.contributor.authorTerry, Leon A.
dc.contributor.authorBerry, Mark J.
dc.contributor.authorLian, Guoping
dc.contributor.authorWang, Shunchun
dc.date.accessioned2021-06-08T09:48:53Z
dc.date.available2021-06-08T09:48:53Z
dc.date.issued2021-05-08
dc.description.abstractInhibition of glucose uptake in the intestine through sodium-dependent glucose transporter 1 (SGLT1) or glucose transporter 2 (GLUT2) may be beneficial in controlling postprandial blood glucose levels. Gallic acid and ten of its derivatives were identified in the active fractions of Terminalia chebula Retz. fructus immaturus, a popular edible plant fruit which has previously been associated with the inhibition of glucose uptake. Gallic acid derivatives (methyl gallate, ethyl gallate, pentyl gallate, 3,4,6-tri-O-galloyl-β-D-glucose, and corilagin) showed good glucose transport inhibition with inhibitory rates of 72.1 ± 1.6%, 71.5 ± 1.4%, 79.9 ± 1.2%, 44.7 ± 1.2%, and 75.0 ± 0.7% at 5 mM D-glucose and/or 56.3 ± 2.3, 52.1 ± 3.2%, 70.2 ± 1.7%, 15.6 ± 1.6%, and 37.1 ± 0.8% at 25 mM D-glucose. However, only 3,4,6-tri-O-galloyl-β-D-glucose and corilagin were confirmed GLUT2-specific inhibitors. Whilst some tea flavonoids demonstrated minimal glucose transport inhibition, their gallic acid derivatives strongly inhibited transport effect with GLUT2 specificity. This suggests that gallic acid structures are crucial for glucose transport inhibition. Plants, such as T. chebula, which contain high levels of gallic acid and its derivatives, show promise as natural functional ingredients for inclusion in foods and drinks designed to control postprandial glucose levels.en_UK
dc.identifier.citationWang H, Fowler MI, Messenger DJ, et al., (2021) Inhibition of the intestinal postprandial glucose transport by gallic acid and gallic acid derivatives. Food and Function, Issue 12, June 2021, pp. 5399-5406en_UK
dc.identifier.issn2042-6496
dc.identifier.urihttps://doi.org/10.1039/D1FO01118A
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16738
dc.language.isoenen_UK
dc.publisherRoyal Society of Chemistryen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectDiabetesen_UK
dc.subjecttea flavonoidsen_UK
dc.subjectgallic acid derivativesen_UK
dc.subjectglucose transporten_UK
dc.subjectTerminalia chebulaen_UK
dc.titleInhibition of the intestinal postprandial glucose transport by gallic acid and gallic acid derivativesen_UK
dc.typeArticleen_UK

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Inhibition_of_intestinal_postprandial_glucose_transport_by_gallic_acid-2021.pdf
Size:
1.95 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Staff publications (SWEE)