Allelic variants of KLK2 gene predict presence of prostate cancer at biopsy

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dc.contributor.authorNna, Emmanuel Okechukwu
dc.contributor.authorTothill, Ibtisam E.
dc.contributor.authorBailey, Tracey
dc.date.accessioned2016-07-26T11:22:37Z
dc.date.available2016-07-26T11:22:37Z
dc.date.issued2016-04-22
dc.description.abstractObjective: Several single nucleotide polymorphisms associated with prostate cancer risk have been reported in recent years. We evaluated polymorphisms in the human glandular kallikrein 2 (KLK2) genes because the protein product of this gene is known to be increased in prostate cancer. Materials and methods: Blood samples were collected from sixty patients who underwent prostate biopsy sectioning, and from their genomic DNA the SNPs in KLK2 gene were investigated by direct DNA sequencing. Another 138 archived prostate tissue sections were also evaluated using the TaqMan SNP genotyping assay. Results: Eighteen known SNPs were identified in the KLK2 gene. The SNPs were located in introns, coding exons and untranslated regions of the gene. Further analysis showed that two of the SNPs were associated with prostate disease. The T/T allele of rs198977 was significantly predictive of the presence of prostate cancer at biopsy and was also associated with high tumour grade. The A/A allele of rs2664155 was also significantly associated with the presence of benign hyperplasia at biopsy. Conclusion: Our results support previous reports of association of the rs198977 SNP with prostate cancer risk and also indicated a link with the disease phenotype. However, the second SNP (rs2664155) was more associated with benign hyperplasia than prostate cancer risk. The method of TaqMan SNP genotyping could be clinically useful in genetic screening and risk stratification of patients for prostate diseases.en_UK
dc.identifier.citationNna EO, Tothill S, Bailey T (2016) Allelic variants of KLK2 gene predict presence of prostate cancer at biopsy. Journal of Cancer Diagn 1:105.en_UK
dc.identifier.urihttp://dx.doi.org/10.4172/2476-2253.1000105
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/10174
dc.language.isoenen_UK
dc.publisherOMICS Internationalen_UK
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAllelic variantsen_UK
dc.subjectSNPen_UK
dc.subjectKLK2 geneen_UK
dc.subjectProstate cancer risken_UK
dc.subjectProstateen_UK
dc.titleAllelic variants of KLK2 gene predict presence of prostate cancer at biopsyen_UK
dc.typeArticleen_UK

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