Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: a critical review

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dc.contributor.authorAli, Waqar
dc.contributor.authorZhang, Hua
dc.contributor.authorJunaid, Muhammad
dc.contributor.authorMao, Kang
dc.contributor.authorXu, Nan
dc.contributor.authorChang, Chuanyu
dc.contributor.authorRasool, Atta
dc.contributor.authorWajahat Aslam, Muhammad
dc.contributor.authorAli, Jamshed
dc.contributor.authorYang, Zhugen
dc.date.accessioned2020-09-03T09:54:35Z
dc.date.available2020-09-03T09:54:35Z
dc.date.issued2020-03-18
dc.description.abstractThis review highlights arsenic (As) and selenium (Se) sources in the environment, their uptake in the soil-plant system, interactions between these metals and the associated toxicity in major biological compartments, which may assist in addressing the hazardous impacts associated with As and Se contamination. The interaction between As and Se is a critical factor for a detailed systematic understanding of the transportation, environmental fate, and associated toxicological effects of these metalloids in plants, animals, and humans. Arsenic and Se induce cytotoxicity and genotoxicity through the generation of reactive oxygen species (ROS). Compared to arsenite (AsIII), methylated arsenicals, including methylarsonous acid (MAsIII) and dimethylarsinous acids (DMAsIII), exhibit more cytotoxic and genotoxic potential to inhibit more potent enzymes and activate the protein AP˗1, which is a critical marker of genetic stability. Methylated AsIII and its associated metabolites are well-known potential carcinogens that induce toxicity by blocking Se metabolism pathway. The imbalance of Se compounds can lead to the generation of ROS, which can inhibit or decrease genomic stability. The As and Se nexus also affect cellular signaling through activation of transcription factors such as NFκB and AP-1.en_UK
dc.identifier.citationAli W, Zhang H, Junaid M, et al., (2020) Insights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: A critical review. Critical Reviews in Environmental Science and Technology, Available online 18 March 2020en_UK
dc.identifier.issn1064-3389
dc.identifier.urihttps://doi.org/10.1080/10643389.2020.1740042
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/15747
dc.language.isoenen_UK
dc.publisherTaylor and Francisen_UK
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectArsenic-seleniumen_UK
dc.subjectcomplex-interactionsen_UK
dc.subjecttoxicityen_UK
dc.titleInsights into the mechanisms of arsenic-selenium interactions and the associated toxicity in plants, animals, and humans: a critical reviewen_UK
dc.typeArticleen_UK

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