Ten millennia of hepatitis B virus evolution

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dc.contributor.authorKocher, Arthur
dc.contributor.authorPapac, Luka
dc.contributor.authorBarquera, Rodrigo
dc.contributor.authorKey, Felix M.
dc.contributor.authorSpyrou, Maria A.
dc.contributor.authorHübler, Ron
dc.contributor.authorRohrlach, Adam B.
dc.contributor.authorAron, Franziska
dc.contributor.authorStahl, Raphaela
dc.contributor.authorWissgott, Antje
dc.contributor.authoret al.
dc.date.accessioned2021-11-12T10:20:45Z
dc.date.available2021-11-12T10:20:45Z
dc.date.issued2021-10-07
dc.description(c) The Authors
dc.description.abstractHepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.en_UK
dc.identifier.citationKocher A, Papac L, Barquera R, et al. (2021) Ten millennia of hepatitis B virus evolution. Science, Volume 374, Issue 6564, October 2021, pp. 182-188en_UK
dc.identifier.issn0036-8075
dc.identifier.urihttps://doi.org/10.1126/science.abi5658
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/17264
dc.language.isoenen_UK
dc.publisherAmerican Association for the Advancement of Scienceen_UK
dc.rights(c) The Authors
dc.titleTen millennia of hepatitis B virus evolutionen_UK
dc.typeArticleen_UK

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