CRISPR-enabled sensors for rapid monitoring of environmental contaminants

Simple item page
dc.contributor.authorWang, Yiting
dc.contributor.authorPan, Yuwei
dc.contributor.authorHan, Wenchao
dc.contributor.authorRossi, Carla Spatola
dc.contributor.authorHui, Qingxin
dc.contributor.authorGuo, Ying
dc.contributor.authorOwoseni, Mojisola Christiana
dc.contributor.authorMcAdam, Ewan
dc.contributor.authorYong, Yang-Chun
dc.contributor.authorWang, Baojun
dc.contributor.authorYang, Zhugen
dc.date.accessioned2025-03-12T15:26:00Z
dc.date.available2025-03-12T15:26:00Z
dc.date.freetoread2025-03-12
dc.date.issued2025-03-01
dc.date.pubOnline2025-01-09
dc.description.abstractThere is increasing attention on the impacts of contaminants on environmental and human health. To better understand the potential threat to ecosystems and human health, biosensing has played an important role in monitoring contaminants and biomarkers. In the past decade, the integration of CRISPR-Cas systems with technologies like microfluidic devices and isothermal amplification methods has paved the way for developing advanced sensors for environmental surveillance. Here we discuss the recent progress of various CRISPR-Cas systems to develop new biosensing devices, ranging from the fundamental mechanisms to their practical applications. We present a comprehensive and critical overview on the current state-of-the-art of CRISPR-Cas-based sensing platforms, including for both nucleic acid and non-nucleic acid contaminants, as well as portable engineered systems for on-site detection. We also provide the prospects of CRISPR-Cas systems for next-generation environmental surveillance, together with emerging technologies such as data science and artificial intelligence.
dc.description.journalNameTrAC Trends in Analytical Chemistry
dc.description.sponsorshipRoyal Academy of Engineering, Natural Environment Research Council, Biotechnology and Biological Sciences Research Council, National Natural Science Foundation of China, Leverhulme Trust
dc.description.sponsorshipThe work is supported by UK Royal Academy of Engineering (FF\1920\1\36), UKRI BBSRC EBIC Engineering Biological Innovation Centre (BB/Y008332/1) and (BB/X012840/1), and UKRI BBSRC EBNet, National Key R&D Program of China (2023YFF1204500), "Pioneer" and "Leading Goose" R&D Program of Zhejiang (2024C03011). ZY thanks Leverhulme Trust Research Leadership Awards (RL-2022-041) and UKRI NERC Fellowship grant (NE/R013349/2).
dc.identifier.citationWang Y, Pan Y, Han W, et al., (2025) CRISPR-enabled sensors for rapid monitoring of environmental contaminants. TrAC Trends in Analytical Chemistry, Volume 184, March 2025, Article number 118128en_UK
dc.identifier.eissn1879-3142
dc.identifier.elementsID561695
dc.identifier.issn0165-9936
dc.identifier.paperNo118128
dc.identifier.urihttps://doi.org/10.1016/j.trac.2024.118128
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23598
dc.identifier.volumeNo184
dc.languageEnglish
dc.language.isoen
dc.publisherElsevieren_UK
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S0165993624006113?via%3Dihub
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCRISPR-Casen_UK
dc.subjectPortable sensorsen_UK
dc.subjectWater contaminantsen_UK
dc.subjectEnvironmental monitoringen_UK
dc.subject3401 Analytical Chemistryen_UK
dc.subject34 Chemical Sciencesen_UK
dc.subjectBiotechnologyen_UK
dc.subjectBioengineeringen_UK
dc.subject3 Good Health and Well Beingen_UK
dc.titleCRISPR-enabled sensors for rapid monitoring of environmental contaminantsen_UK
dc.typeArticle
dc.type.subtypeReview
dcterms.dateAccepted2024-12-30

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
CRISPR-enabled_sensors_for_rapid_monitoring-2025.pdf
Size:
1.61 MB
Format:
Adobe Portable Document Format
Description:
Accepted version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.63 KB
Format:
Plain Text
Description:
Download

Collections

Staff publications (SWEE)