Revisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor

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dc.contributor.authorCox, Rylan
dc.contributor.authorSalonitis, Konstantinos
dc.contributor.authorRebrov, Evgeny
dc.contributor.authorImpey, Susan A.
dc.date.accessioned2022-07-25T15:48:39Z
dc.date.available2022-07-25T15:48:39Z
dc.date.issued2022-07-18
dc.description.abstractAbstract An oscillatory baffled flow reactor (OBR) has been designed with 60 interbaffled cells. The baffled columns of 40 mm internal diameter together result in a reactor length of 5740 mm. The oscillatory amplitude and frequency were in the range of 2–12 mm and 0.3–2 Hz, respectively. The report investigates the impact of U-bends and the number of reactor sections on axial dispersion for scale-up feasibility. A prediction model using operating parameters has been developed to maximize plug flow conditions using the tanks-in-series (TiS) model. The maximum TiS value was 13.38 in a single column compared to 43.68 in the full reactor at a velocity ratio of 2.27 using oscillatory parameters 8 mm and 0.3 Hz. The mixing efficiency along the reactor was found to decrease after each column at amplitudes <6 mm compared to amplitudes up to 12 mm, where a negligible impact was observed. U-bend geometry had a significant role in the decrease of TiS values.en_UK
dc.identifier.citationCox R, Salonitis K, Rebrov E, Impey SA. (2022) Revisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor. Industrial and Engineering Chemistry Research, Volume 61, Issue 30, 3 August 2022, pp. 11181–11196en_UK
dc.identifier.issn0888-5885
dc.identifier.urihttps://doi.org/10.1021/acs.iecr.2c00822
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18228
dc.language.isoenen_UK
dc.publisherAmerican Chemical Societyen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOscillatory Baffled Flow Reactoren_UK
dc.subjectTanks-in-Seriesen_UK
dc.subjectVelocity Ratioen_UK
dc.subjectScale-Up Feasibilityen_UK
dc.subjectU-Bendsen_UK
dc.titleRevisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactoren_UK
dc.typeArticleen_UK

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