Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks

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dc.contributor.authorKumar, Vinod
dc.contributor.authorAgrawal, Deepti
dc.contributor.authorBommareddy, Rajesh Reddy
dc.contributor.authorIslam, M. Ahsanul
dc.contributor.authorJacob, Samuel
dc.contributor.authorBalan, Venkatesh
dc.contributor.authorSingh, Vijai
dc.contributor.authorThakur, Vijay Kumar
dc.contributor.authorNavani, Naveen Kumar
dc.contributor.authorScrutton, Nigel S.
dc.date.accessioned2023-11-20T16:12:22Z
dc.date.available2023-11-20T16:12:22Z
dc.date.issued2023-11-06
dc.description.abstractThe circular economy is anticipated to bring a disruptive transformation in manufacturing technologies. Robust and industrial scalable microbial strains that can simultaneously assimilate and valorize multiple carbon substrates are highly desirable, as waste bioresources contain substantial amounts of renewable and fermentable carbon, which is diverse. Lignocellulosic biomass (LCB) is identified as an inexhaustible and alternative resource to reduce global dependence on oil. Glucose, xylose, and arabinose are the major monomeric sugars in LCB. However, primary research has focused on the use of glucose. On the other hand, the valorization of pentose sugars, xylose, and arabinose, has been mainly overlooked, despite possible assimilation by vast microbial communities. The present review highlights the research efforts that have explicitly proven the suitability of arabinose as the starting feedstock for producing various chemical building blocks via biological routes. It begins by analyzing the availability of various arabinose-rich biorenewable sources that can serve as potential feedstocks for biorefineries. The subsequent section outlines the current understanding of arabinose metabolism, biochemical routes prevalent in prokaryotic and eukaryotic systems, and possible products that can be derived from this sugar. Further, currently, exemplar products from arabinose, including arabitol, 2,3-butanediol, 1,2,3-butanetriol, ethanol, lactic acid, and xylitol are discussed, which have been produced by native and non-native microbial strains using metabolic engineering and genome editing tools. The final section deals with the challenges and obstacles associated with arabinose-based production, followed by concluding remarks and prospects.en_UK
dc.identifier.citationKumar V, Agrawal D, Bommareddy RR, et al., (2023) Arabinose as an overlooked sugar for microbial bioproduction of chemical building blocks. Critical Reviews in Biotechnology, Available online 6 Novemberen_UK
dc.identifier.issn0738-8551
dc.identifier.urihttps://doi.org/10.1080/07388551.2023.2270702
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/20563
dc.language.isoenen_UK
dc.publisherTaylor and Francisen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectArabinoseen_UK
dc.subjectarabitolen_UK
dc.subject2,3-butanediolen_UK
dc.subject1,2,3-butanetriolen_UK
dc.subjectcircular biorefineriesen_UK
dc.subjectethanolen_UK
dc.subjectlactic aciden_UK
dc.subjectmetabolic engineeringen_UK
dc.subjectxylitolen_UK
dc.titleArabinose as an overlooked sugar for microbial bioproduction of chemical building blocksen_UK
dc.typeArticleen_UK

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