Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles

Simple item page
dc.contributor.authorKorposh, Sergiy
dc.contributor.authorChianella, Iva
dc.contributor.authorGuerreiro, Antonio R.
dc.contributor.authorCaygill, J. S.
dc.contributor.authorPiletsky, Sergey A.
dc.contributor.authorJames, Stephen W.
dc.contributor.authorTatam, Ralph P.
dc.date.accessioned2016-10-24T11:42:46Z
dc.date.available2016-10-24T11:42:46Z
dc.date.issued2014-02-25
dc.description.abstractAn optical fibre long period grating (LPG) sensor modified with molecularly imprinted polymer nanoparticles (nanoMIPs) for the specific detection of antibiotics is presented. The operation of the sensor is based on the measurement of changes in refractive index induced by the interaction of nanoMIPs deposited onto the cladding of the LPG with free vancomycin (VA). The binding of nanoMIPs to vancomycin was characterised by a binding constant of 4.3 ± 0.1 × 10−8 M. The lowest concentration of analyte measured by the fibre sensor was 10 nM. In addition, the sensor exhibited selectivity, as much smaller responses were obtained for high concentrations (∼700 μM) of other commonly prescribed antibiotics such as amoxicillin, bleomycin and gentamicin. In addition, the response of the sensor was characterised in a complex matrix, porcine plasma, spiked with 10 μM of VA.en_UK
dc.identifier.citationKorposh S, Chianella I, Guerreiro A, et al. (2014) Selective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticles. Analyst, Volume 139, Issue 9, May 2014, pp. 2229-2236en_UK
dc.identifier.cris2420545
dc.identifier.issn0003-2654
dc.identifier.urihttp://dx.doi.org/10.1039/c3an02126b
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/10846
dc.language.isoenen_UK
dc.publisherRoyal Society of Chemistryen_UK
dc.rightsAttribution 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.titleSelective vancomycin detection using optical fibre long period gratings functionalised with molecularly imprinted polymer nanoparticlesen_UK
dc.typeArticleen_UK

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Selective_vancomycin_detection-2014.pdf
Size:
1.26 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Staff publications (SATM)