Comparative highly efficient production of β-glucan by Lasiodiplodia theobromae CCT 3966 and its multiscale characterization

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dc.contributor.authorAscencio, Jesús J.
dc.contributor.authorPhilippini, Rafael R.
dc.contributor.authorGomes, Fabricio M.
dc.contributor.authorPereira, Félix M.
dc.contributor.authorSilva, Silvio S. da
dc.contributor.authorKumar, Vinod
dc.contributor.authorChandel, Anuj K.
dc.date.accessioned2021-07-20T19:44:26Z
dc.date.available2021-07-20T19:44:26Z
dc.date.issued2021-06-07
dc.description.abstractLasiodiplodan, a (1→6)-β-d-glucan, is an exopolysaccharide with high commercial value and many applications in food, pharmaceuticals, and cosmetics. Current industrial production of β-glucans from crops is mostly by chemical routes generating hazardous and toxic waste. Therefore, alternative sustainable and eco-friendly pathways are highly desirable. Here, we have studied the lasiodiplodan production from sugarcane bagasse (SCB), a major lignocellulosic agricultural residue, by Lasiodiplodia theobromae CCT 3966. Lasiodiplodan accumulated on SCB hydrolysate (carbon source) supplemented with soybean bran or rice bran (nitrogen source) was 16.2 [6.8 × 103 Da] and 22.0 [7.6 × 103 Da] g/L, respectively. Lasiodiplodan showed high purity, low solubility, pseudoplastic behavior and was composed of glucose units. Moreover, the exopolysaccharides were substantially amorphous with moderate thermal stability and similar degradation temperatures. To our knowledge, this is the first report on the highest production of SCB-based lasiodiplodan to date. L. theobromae, as a microbial cell factory, demonstrated the commercial potential for the sustainable production of lasiodiplodan from renewable biomass feedstock.en_UK
dc.identifier.citationAscencio JJ, Philippini RR, Gomes FM, et al., (2021) Comparative highly efficient production of β-glucan by Lasiodiplodia theobromae CCT 3966 and its multiscale characterization. Fermentation, Volume 7, Issue 3, September 2021, Article number 108en_UK
dc.identifier.issn2311-5637
dc.identifier.urihttps://doi.org/10.3390/fermentation7030108
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/16903
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectlasiodiplodanen_UK
dc.subjectLasiodiplodia theobromaeen_UK
dc.subjectsoybean branen_UK
dc.subjectrice branen_UK
dc.subjectsugarcane bagasseen_UK
dc.titleComparative highly efficient production of β-glucan by Lasiodiplodia theobromae CCT 3966 and its multiscale characterizationen_UK
dc.typeArticleen_UK

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