An ultrasonography-based approach for tissue modelling to inform photo-therapy treatment strategies

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dc.contributor.authorKallepalli, Akhill
dc.contributor.authorHalls, James
dc.contributor.authorJames, David B.
dc.contributor.authorRichardson, Mark A.
dc.date.accessioned2022-02-02T13:59:17Z
dc.date.available2022-02-02T13:59:17Z
dc.date.issued2022-01-19
dc.description.abstractCurrently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high resolution without the drawbacks of ionising radiation. This research proposes a low-cost, non-invasive and real-time protocol for informing photo-therapy procedures using ultrasound imaging. We combine currently available ultrasound procedures with Monte Carlo methods for assessing light transport and photo-energy deposition in the tissue. The measurements from high-resolution ultrasound scans are used as input for optical simulations. Consequently, this provides a pipeline that will inform medical practitioners for better therapy strategy planning. While validating known inferences of light transport through biological tissue, our results highlight the range of information such as temporal monitoring and energy deposition at varying depths. This process also retains the flexibility of testing various wavelengths for individual-specific geometries and anatomy.en_UK
dc.identifier.citationKallepalli A, Halls J, James DB, Richardson MA. (2022) An ultrasonography-based approach for tissue modelling to inform photo-therapy treatment strategies, Journal of Biophotonics, Volume 15, Issue 4, April 2022, Article number e202100275en_UK
dc.identifier.eissn1864-0648
dc.identifier.issn1864-063X
dc.identifier.urihttps://doi.org/10.1002/jbio.202100275
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/17534
dc.language.isoenen_UK
dc.publisherWileyen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectdiagnosticsen_UK
dc.subjectMonte Carloen_UK
dc.subjectoptical interactionsen_UK
dc.subjectphoto-modulationen_UK
dc.subjectray tracingen_UK
dc.subjectultrasound imagingen_UK
dc.titleAn ultrasonography-based approach for tissue modelling to inform photo-therapy treatment strategiesen_UK
dc.typeArticleen_UK

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