Microarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgrounds

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dc.contributor.authorAdams, G. J.
dc.contributor.authorCook, R. B.
dc.contributor.authorHutchinson, J. R.
dc.contributor.authorZioupos, Peter
dc.date.accessioned2022-06-24T09:02:09Z
dc.date.available2022-06-24T09:02:09Z
dc.date.issued2022-06-17
dc.description.abstractThe microarchitecture of bone both results from and in turn affects the remodelling process. Bone-specific surface, for instance, is one of these important microarchitectural parameters because remodelling is also considered to be a surface-mediated phenomenon (Berli et al.[1]). An understanding of these structural parameters across the widest possible range of porosity is essential to illuminating how bone reacts to disease, in different skeletal sites and in either its cancellous or cortical forms. 112 samples from an elephant femur were examined by micro-computed tomography (μCT), 31 of which contained both mineralised and demineralised tissue. A critical factor in all scans is setting the correct threshold (with background the surrounding medium) and hence 3 different backgrounds were used: air, water and collagen. The effect of the 3 background thresholds on the physical characteristics of bone (BS/TV, BS/BV, TbSp, TbTh, Dmat, vs BV/TV) was then determined. The results showed that using a threshold set by the collagen background had a profound effect on the histomorphometry bone parameters when assessed by μCT. However, the differences between air and water were not significant, suggesting that comparable data can be produced in a laboratory environment when scanning porous bone samples under either wet or dry conditions– counter to common belief. Determining which is more suitable, air or water, in laboratory and in clinical μCT imaging is important to improve the quality and relevance of biomechanics research. The data with collagen as the threshold were illuminating as they showed that remodelling rates and the relative organic to mineral presence varied with BV/TV, concurring with some other recent studies [2,3,4].en_UK
dc.description.sponsorshipEngineering and Physical Sciences Research Council (EPSRC): GR/N33225, GR/N33102 and GR/ M59167. Biotechnology and Biological Sciences Research Council (BBSRC): BB/C516844/1.en_UK
dc.identifier.citationAdams GJ, Cook RB, Hutchinson JR, Zioupos P. (2022) Microarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgrounds, Medical Engineering and Physics, Volume 106, August 2022, Article number 103828en_UK
dc.identifier.eissn1873-4030
dc.identifier.issn1350-4533
dc.identifier.urihttps://doi.org/10.1016/j.medengphy.2022.103828
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/18060
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBoneen_UK
dc.subjectCancellousen_UK
dc.subjectCorticalen_UK
dc.subjectDensityen_UK
dc.subjectPorosityen_UK
dc.subjectBV/TVen_UK
dc.subjectSpecific surfaceen_UK
dc.subjectμCTen_UK
dc.titleMicroarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgroundsen_UK
dc.typeArticleen_UK

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