Additive manufacturing and physicomechanical characteristics of PEGDA hydrogels: recent advances and perspective for tissue engineering

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dc.contributor.authorKhalili, Mohammad Hakim
dc.contributor.authorZhang, Rujing
dc.contributor.authorWilson, Sandra
dc.contributor.authorGoel, Saurav
dc.contributor.authorImpey, Susan A.
dc.contributor.authorAria, Adrianus Indrat
dc.date.accessioned2023-05-23T10:53:22Z
dc.date.available2023-05-23T10:53:22Z
dc.date.issued2023-05-17
dc.description.abstractIn this brief review, we discuss the recent advancements in using poly(ethylene glycol) diacrylate (PEGDA) hydrogels for tissue engineering applications. PEGDA hydrogels are highly attractive in biomedical and biotechnology fields due to their soft and hydrated properties that can replicate living tissues. These hydrogels can be manipulated using light, heat, and cross-linkers to achieve desirable functionalities. Unlike previous reviews that focused solely on material design and fabrication of bioactive hydrogels and their cell viability and interactions with the extracellular matrix (ECM), we compare the traditional bulk photo-crosslinking method with the latest three-dimensional (3D) printing of PEGDA hydrogels. We present detailed evidence combining the physical, chemical, bulk, and localized mechanical characteristics, including their composition, fabrication methods, experimental conditions, and reported mechanical properties of bulk and 3D printed PEGDA hydrogels. Furthermore, we highlight the current state of biomedical applications of 3D PEGDA hydrogels in tissue engineering and organ-on-chip devices over the last 20 years. Finally, we delve into the current obstacles and future possibilities in the field of engineering 3D layer-by-layer (LbL) PEGDA hydrogels for tissue engineering and organ-on-chip devices.en_UK
dc.identifier.citationKhalili MH, Zhang R, Wilson S, et al.,(2023) Additive manufacturing and physicomechanical characteristics of PEGDA hydrogels: recent advances and perspective for tissue engineering. Polymers, Volume 15, Issue 10, May 2023, Article number 2341en_UK
dc.identifier.issn2073-4360
dc.identifier.urihttps://doi.org/10.3390/polym15102341
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/19702
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjecthydrogelsen_UK
dc.subjectpoly(ethylene glycol)diacrylateen_UK
dc.subjecttissue engineeringen_UK
dc.subjectthree-dimensionalen_UK
dc.subjectprintingen_UK
dc.titleAdditive manufacturing and physicomechanical characteristics of PEGDA hydrogels: recent advances and perspective for tissue engineeringen_UK
dc.typeArticleen_UK

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