Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development

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dc.contributor.authorDiez Benavente, Ernest
dc.contributor.authorOresegun, Damilola R.
dc.contributor.authorFlorez de Sessions, Paola
dc.contributor.authorWalker, Eloise M.
dc.contributor.authorRoper, Cally
dc.contributor.authorDombrowski, Jamille G.
dc.contributor.authorde Souza, Rodrigo M.
dc.contributor.authorMarinho, Claudio R. F.
dc.contributor.authorSutherland, Colin J.
dc.contributor.authorHibberd, Martin L.
dc.contributor.authorMohareb, Fady R.
dc.contributor.authorBaker, David A.
dc.contributor.authorClark, Taane G.
dc.contributor.authorCampino, Susana
dc.date.accessioned2018-10-24T13:44:38Z
dc.date.available2018-10-24T13:44:38Z
dc.date.issued2018-10-18
dc.description.abstractMalaria infection during pregnancy, caused by the sequestering of Plasmodium falciparum parasites in the placenta, leads to high infant mortality and maternal morbidity. The parasite-placenta adherence mechanism is mediated by the VAR2CSA protein, a target for natural occurring immunity. Currently, vaccine development is based on its ID1-DBL2Xb domain however little is known about the global genetic diversity of the encoding var2csa gene, which could influence vaccine efficacy. In a comprehensive analysis of the var2csa gene in >2,000 P. falciparum field isolates across 23 countries, we found that var2csa is duplicated in high prevalence (>25%), African and Oceanian populations harbour a much higher diversity than other regions, and that insertions/deletions are abundant leading to an underestimation of the diversity of the locus. Further, ID1-DBL2Xb haplotypes associated with adverse birth outcomes are present globally, and African-specific haplotypes exist, which should be incorporated into vaccine design.en_UK
dc.identifier.citationErnest Diez Benavente, Damilola R. Oresegun, Paola Florez de Sessions, et al., Global genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine development. Scientific Reports, Volume 8, Issue 1, Article number 15429en_UK
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-018-33767-3
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/13562
dc.language.isoenen_UK
dc.publisherNature Publishing Groupen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGlobal genetic diversity of var2csa in Plasmodium falciparum with implications for malaria in pregnancy and vaccine developmenten_UK
dc.typeArticleen_UK

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