The untargeted metabolomic analysis of Ammodaucus leucotrichus Coss. & Dur. seeds reveals previously undescribed polar lignans and terpenoids

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dc.contributor.authorKisiriko, Musa
dc.contributor.authorBitchagno, Gabin T. M.
dc.contributor.authorNoleto-Dias, Clarice
dc.contributor.authorNaboulsi, Imane
dc.contributor.authorAnastasiadi, Maria
dc.contributor.authorTerry, Leon A.
dc.contributor.authorSobeh, Mansour
dc.contributor.authorBeale, Michael H.
dc.contributor.authorWard, Jane L.
dc.date.accessioned2025-01-28T14:05:10Z
dc.date.available2025-01-28T14:05:10Z
dc.date.freetoread2025-01-28
dc.date.issued2025-02-01
dc.date.pubOnline2024-11-21
dc.description.abstractThe polar metabolome of the medicinal plant Ammodaucus leucotrichus Coss. & Dur. has not been comprehensively characterised. In this study, the chemical composition of a water/methanol (4:1) extract of seeds was determined through a combination of UHPLC-MS and NMR techniques. Sixty compounds were identified from the extract with 36 of these confirmed using UHPLC-MS and/or NMR data while the remaining 24 were given putative identifications based on UHPLC-MS data. The compounds included lignans, terpenes, phenolics, flavonoids, and alkaloid derivatives together with some amino- and organic acids. Of these 2 terpenoids and 3 lignans were found to be novel and were isolated and structures determined by comprehensive NMR studies. A further novel lignan glycoside was tentatively identified. Together these data represent the most comprehensive profile of this traditional medicinal plant, providing an annotated profile that can form the basis of future correlative metabolomic investigations to determine active principles behind its reported bioactivities.
dc.description.journalNamePhytochemistry Letters
dc.description.sponsorshipThe FP05 project (Bioproducts for African Agriculture), which is funded by OCP Morocco. FP05 is a collaboration between Mohammed VI Polytechnic University, Rothamsted Research and Cranfield University.
dc.format.extentpp. 28-37
dc.identifier.citationKisiriko M, Bitchagno GTM, Noleto-Dias C, et al., (2025) The untargeted metabolomic analysis of Ammodaucus leucotrichus Coss. & Dur. seeds reveals previously undescribed polar lignans and terpenoids. Phytochemistry Letters, Volume 65, February 2025, pp. 28-37
dc.identifier.eissn1876-7486
dc.identifier.elementsID559331
dc.identifier.issn1874-3900
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2024.11.006
dc.identifier.urihttps://dspace.lib.cranfield.ac.uk/handle/1826/23442
dc.identifier.volumeNo65
dc.languageEnglish
dc.language.isoen
dc.publisherElsevier
dc.publisher.urihttps://www.sciencedirect.com/science/article/pii/S1874390024001496?via%3Dihub
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAmmodaucus leucotrichus
dc.subjectApiaceae
dc.subjectUHPLC-MS
dc.subjectNMR
dc.subjectLignan
dc.subjectTerpene
dc.subjectAmmolactone-A
dc.subjectAmmodauside
dc.subjectAmmodaucic acid
dc.subjectAmmodolide
dc.subject3401 Analytical Chemistry
dc.subject34 Chemical Sciences
dc.subjectDietary Supplements
dc.subjectComplementary and Integrative Health
dc.subjectMedicinal & Biomolecular Chemistry
dc.subject3404 Medicinal and biomolecular chemistry
dc.subject3405 Organic chemistry
dc.titleThe untargeted metabolomic analysis of Ammodaucus leucotrichus Coss. & Dur. seeds reveals previously undescribed polar lignans and terpenoids
dc.typeArticle
dc.type.subtypeJournal Article
dcterms.dateAccepted2024-11-04

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