Understanding of colistin usage in food animals and available detection techniques: a review

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dc.contributor.authorKumar, Harsh
dc.contributor.authorChen, Bing-Huei
dc.contributor.authorKuca, Kamil
dc.contributor.authorNepovimova, Eugenie
dc.contributor.authorKaushal, Ankur
dc.contributor.authorNagraik, Rupak
dc.contributor.authorBhatia, Shashi Kant
dc.contributor.authorDhanjal, Daljeet Singh
dc.contributor.authorKumar, Vinod
dc.contributor.authorKumar, Anil
dc.contributor.authorUpadhyay, Navneet Kumar
dc.contributor.authorVerma, Rachna
dc.contributor.authorKumar, Dinesh
dc.date.accessioned2020-10-22T10:46:45Z
dc.date.available2020-10-22T10:46:45Z
dc.date.issued2020-10-16
dc.description.abstractProgress in the medical profession is determined by the achievements and effectiveness of new antibiotics in the treatment of microbial infections. However, the development of multiple-drug resistance in numerous bacteria, especially Gram-negative bacteria, has limited the treatment options. Due to this resistance, the resurgence of cyclic polypeptide drugs like colistin remains the only option. The drug, colistin, is a well-known growth inhibitor of Gram-negative bacteria like Acinetobacter baumanni, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Technological advancements have uncovered the role of the mcr-1(mobilized colistin resistance) gene, which is responsible for the development of resistance in Gram-negative bacteria, which make them distinct from other bacteria without this gene. Additionally, food animals have been determined to be the reservoir for colistin resistance microbes, from which they spread to other hosts. Due to the adverse effects of colistin, many developed countries have prohibited its usage in animal foods, but developing countries are still using colistin in animal food production, thereby imposing a major risk to the public health. Therefore, there is a need for implementation of sustainable measures in livestock farms to prevent microbial infection. This review highlights the negative effects (increased resistance) of colistin consumption and emphasizes the different approaches used for detecting colistin in animal-based foods as well as the challenges associated with its detectionen_UK
dc.identifier.citationKumar H, Chen BH, Kuca K, et al., (2020) Understanding of colistin usage in food animals and available detection techniques: a review. Animals, Volume 10, Issue 10, 2020, Article number 1892en_UK
dc.identifier.issn2076-2615
dc.identifier.urihttps://doi.org/10.3390/ani10101892
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/15909
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmulti-drug resistanceen_UK
dc.subjectfood animalsen_UK
dc.subjectdetection methodsen_UK
dc.subjectcolistinen_UK
dc.subjectantibioticsen_UK
dc.titleUnderstanding of colistin usage in food animals and available detection techniques: a reviewen_UK
dc.typeArticleen_UK

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