Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process

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dc.contributor.authorMatos, Ravenna Lessa
dc.contributor.authorLu, Tiejun
dc.contributor.authorMcConville, Christopher
dc.contributor.authorLeeke, Gary
dc.contributor.authorIngram, Andrew
dc.date.accessioned2018-01-17T15:47:31Z
dc.date.available2018-01-17T15:47:31Z
dc.date.issued2017-12-12
dc.description.abstractDry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.en_UK
dc.identifier.citationRavenna Lessa Matos, Tiejun Lu, Christopher McConville, et al., Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process, Journal of Supercritical Fluids, Volume 141, November 2018, Pages 143-156en_UK
dc.identifier.issn0896-8446
dc.identifier.urihttp://dx.doi.org/10.1016/j.supflu.2017.12.013
dc.identifier.urihttp://dspace.lib.cranfield.ac.uk/handle/1826/12900
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSupercritical antisolventen_UK
dc.subjectFluidized beden_UK
dc.subjectCoatingen_UK
dc.subjectCurcuminen_UK
dc.subjectLactoseen_UK
dc.subjectPulmonary deliveryen_UK
dc.titleAnalysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed processen_UK
dc.typeArticleen_UK

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