Spatial Localization of Biosensor Fluorescence Signals in Human Skin under the Effect of Equalization of the Refractive Index of the Surrounding Medium.

Show simple item record

dc.contributor.author Meglinski, I. V. -
dc.contributor.author Churmakov, D. Y. -
dc.date.accessioned 2011-10-11T07:13:12Z
dc.date.available 2011-10-11T07:13:12Z
dc.date.issued 2004-06-01T00:00:00Z -
dc.identifier.citation Optics and Spectroscopy (English translation of Optika i Spektroskopiya) Volume 96, Issue 6, 2004, Pages 946-951. -
dc.identifier.issn 0030-400X -
dc.identifier.uri http://dspace.lib.cranfield.ac.uk/handle/1826/971
dc.description.abstract A priority line of biomedical applications of optics is the development of noninvasive diagnostic methods based on the scanning of fluorescence radiation of biosensors embedded in biological tissue. Their main advantage is a high sensitivity and selectivity with respect to given parameters of tissues and their variations. In this study, we present a method for and results of modeling of excitation and propagation of fluorescence radiation in a multilayer randomly inhomogeneous highly scattering and absorbing medium imitating human skin. The model takes into account the spatially inhomogeneous distribution of skin fluorophores and their photophysical characteristics. Both the spatial distribution of fluorescence of skin tissues and the possibility of localization of a detected fluorescence signal are studied. The spatial distribution of fluorescence centers (fluorophores) in the medium is assumed to closely follow the spatial distribution of collagen fibers of the skin. The equalization of the refractive indices at the air–skin interface is shown to lead to a higher degree of localization of the fluorescence signal detected from a biosensor located in a near-surface skin laye en_UK
dc.language.iso en_UK -
dc.publisher Springer Science Business Media en_UK
dc.title Spatial Localization of Biosensor Fluorescence Signals in Human Skin under the Effect of Equalization of the Refractive Index of the Surrounding Medium. en_UK
dc.type Article -


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search CERES


Browse

My Account

Statistics