Citation:
J.J. Ramsden, D.M. Allen, D.J. Stephenson, J.R. Alcock, G.N. Peggs, G. Fuller and G. Goch. The design and manufacture of biomedical surfaces. Cirp Annals-Manufacturing Technology, 2007, Volume 56, Issue 2, pp687-711
Abstract:
Surfaces are the primary place of contact between a biomaterial and its host
organism. Typically, prostheses have to fulfil demanding structural and
mechanical requirements, yet the material best for those functions may be bio-
incompatible. Surface treatment or coating provides a means to overcome that
problem, which means both integration within the host physiology and
stabilization with respect to corrosion and wear. The adsorption of
biomacromolecules is pivotal for biocompatibility. The impossibility of keeping
proteins away from most implants means that very careful consideration has to be
given to this aspect, and both prevention (for bloodstream implants) and
promotion (for bone replacement and repair) occur with equal importance. This
paper also considers the metrology of relevant physical and chemical aspects of
surfaces.
