Computational nanoscience and molecular modelling of shock wave interactions with biological membranes

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dc.contributor.advisor Asproulis, N.
dc.contributor.advisor Drikakis, Dimitris Sourmaidou, Damiani 2012-06-26T11:40:20Z 2012-06-26T11:40:20Z 2011
dc.description.abstract Lateral diffusion of membrane components (lipids and proteins) is an important membrane property to measure since the essential process of absorption of anti-cancer and other drugs -some of which are not soluble in lipids and therefore would not be able to penetrate the cell membrane through passive diffusion- lies on it. In particular, the procedure of diffusion into the cell cytoplasm is reliant on free volumes in the membrane (passive diffusion) as well as carrier proteins (facilitated diffusion). By enhancing the mobility of lipids and/or proteins, the possibility of the carrier protein to "encapsulate" pharmacological components maxim- izes, as a "scanning" of the proteins gets performed due to the fluid phase of a biological membrane. At the same time, the increased mobility of the lipids facilitates the passage of lipid-soluble molecules into the cell. Thus, given that the success of anticancer treatments heavily depends on their absorption by the cell, a significant enhancement of the cell mem- brane permeability (permeabilisation) is rendered vital to the applicability of the technique. For this reason, there is augmented interest in combined methods such as Nanotechnology based drug delivery that is focused on the development of optimally designed therapeutic agents along with the application of shock waves to enhance the membrane permeability to the agents. This study examines the impact of shock waves on a numerical model of a biological membrane. Cont/d. en_UK
dc.language.iso en en_UK
dc.publisher Cranfield University en_UK
dc.rights © Cranfield University 2011. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder. en_UK
dc.subject Molecular Dynamics en_UK
dc.subject biological membrane en_UK
dc.subject cancer treatment en_UK
dc.subject incident angle en_UK
dc.subject lateral diffusion en_UK
dc.subject drug delivery, en_UK
dc.subject NAMD en_UK
dc.title Computational nanoscience and molecular modelling of shock wave interactions with biological membranes en_UK
dc.type Thesis or dissertation en_UK
dc.type.qualificationlevel Doctoral en_UK
dc.type.qualificationname PhD en_UK

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