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|Document Type: ||Article|
|Title: ||Meeting report: risk assessment of tamiflu use under pandemic conditions|
|Authors: ||Singer, Andrew C.|
Howard, Bruce M.
Johnson, Andrew C.
Knowles, Chris J.
Caracciolo, Anna Barra
Brian, Jayne V.
Dempsey, Michael J.
Kelleher, Samuel L.
Nunn, Miles A.
Sacca, Maria Ludovica
Straub, Jürg Oliver
|Issue Date: ||2008|
|Citation: ||Andrew C. Singer, Bruce M. Howard, Andrew C. Johnson, et al. Meeting report: risk assessment of tamiflu use under pandemic conditions. Environmental Health Perspectives, Volume 116, number 11, November 2008, pp1563-1567|
|Abstract: ||On 3 October 2007, 40 participants with diverse expertise attended the workshop
Tamiflu and the Environment: Implications of Use under Pandemic Conditions to
assess the potential human health impact and environmental hazards associated
with use of Tamiflu during an influenza pandemic. Based on the identification
and risk-ranking of knowledge gaps, the consensus was that oseltamivir
ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to
pose an ecotoxicologic hazard to freshwater organisms. OC in river water might
hasten the generation of OC-resistance in wildfowl, but this possibility seems
less likely than the potential disruption that could be posed by OC and other
pharmaceuticals to the operation of sewage treatment plants. The work-group
members agreed on the following research priorities: a) available data on the
ecotoxicology of OE-P and OC should be published; b) risk should be assessed for
OC-contaminated river water generating OC-resistant viruses in wildfowl; c)
sewage treatment plant functioning due to microbial inhibition by neuraminidase
inhibitors and other antimicrobials used during a pandemic should be
investigated: and e realistic worst-case exposure scenarios should be developed.
Additional modeling would be useful to identify localized areas within river
catchments that might be prone to high pharmaceutical concentrations in sewage
treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers
opportunities for researchers to assess how much OC enters and persists in the
|Appears in Collections:||Staff publications - School of Applied Sciences|
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