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Please use this identifier to cite or link to this item: http://dspace.lib.cranfield.ac.uk/handle/1826/7057

Document Type: Article
Title: Meeting report: risk assessment of tamiflu use under pandemic conditions
Authors: Singer, Andrew C.
Howard, Bruce M.
Johnson, Andrew C.
Knowles, Chris J.
Jackman, Simon
Accinelli, Cesare
Caracciolo, Anna Barra
Bernard, Ian
Bird, Stephen
Boucard, Tatiana
Boxall, Alistair
Brian, Jayne V.
Cartmell, Elise
Chubb, Chris
Churchley, J.
Costigan, Sandra
Crane, Mark
Dempsey, Michael J.
Dorrington, Bob
Ellor, Brian
Fick, Jerker
Holmes, John
Hutchinson, Tom
Karcher, Franz
Kelleher, Samuel L.
Marsden, Peter
Noone, Gerald
Nunn, Miles A.
Oxford, John
Rachwal, Tony
Roberts, Noel
Roberts, Mike
Sacca, Maria Ludovica
Sanders, Matthew
Straub, Jürg Oliver
Terry, Adrian
Thomas, Dean
Toovey, Stephen
Townsend, Rodney
Vouivoulis, Nikolaos
Watts, Chris
Issue Date: 2008
Citation: Andrew C. Singer, Bruce M. Howard, Andrew C. Johnson, et al. Meeting report: risk assessment of tamiflu use under pandemic conditions. Environmental Health Perspectives, Volume 116, number 11, November 2008, pp1563-1567
Abstract: On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OC-resistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The work-group members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated: and e realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.
URI: http://dx.doi.org/10.1289/ehp.11310
Appears in Collections:Staff publications - School of Applied Sciences

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