Abstract:
It is generally accepted that the majority of Gram-negative and Gram-positive bacteria
communicate via production and sensing of small signal molecules, autoinducers. The ability
of bacteria to sense their population density is termed quorum sensing (QS). Quorum sensing
controls certain phenotypic traits, particularly virulence factors and biofilm formation. In this
project a new solution for the attenuation of quorum sensing which involves selective
sequestering of the signal molecules using rationally designed synthetic polymers was
explored. Cont/d.
