Citation:
Irene Mijangos, Fernando Navarro-Villoslada, Antonio Guerreiro, Elena Piletska,
Iva Chianella, Kal Karim, Anthony Turner, Sergey Piletsky, Influence of
initiator and different polymerisation conditions on performance of molecularly
imprinted polymers, Biosensors and Bioelectronics, Volume 22, Issue 3, Selected
Papers from Synthetic Receptors 2005, 15 September 2006, Pages 381-387
Abstract:
A set of polymers was imprinted with (−)-ephedrine using two different
initiators. A chemometrics approach was used to optimise experiments aimed at
analysis of the interplay of parameters such as polymerisation time, temperature
and percentage of initiator. The results presented demonstrate the importance of
keeping the right balance between these various parameters of polymerisation
conditions. It is shown that enhancing one single parameter such as polymer
rigidity does not necessarily improve polymer performance. In general it could
be concluded that MIPs should be synthesised over a long period of time using
low concentration of initiator and low temperature. The best selectivity was
achieved for polymers prepared by photo-initiation with 2,2-dimethoxy-2-
phenylacetophenone as initiato
