Regulatory T cells (Tregs) have a central role in the maintenance of tolerance to self-
antigens and the prevention of autoimmune disease. This study used an integrative
systems biology approach to identify tolerogenic ...
Lateral flow immunoassays provide quick, qualitative detection of biomolecules. They
are designed to be easy to use, cheap and suitable for applications away from the
laboratory.
Most lateral flow assays detect a single ...
Lean principles have been used in manufacturing organisations globally for
many years. Lean principles are increasingly being successfully applied with
respect to the delivery of healthcare services on a global scale.
Lean ...
Breast cancer is the most frequent cancer in women in developed countries. Endocrine
treatment is indicated to the majority of breast cancer patients. However, in some cases
it does not work despite the current clinical ...
In order to manage a modern day gas turbine plant, an operator must collect and
disseminate a wide range of knowledge, for decision making and for reporting to high
level management. Often, an operator must also justify ...
Controlled laboratory experiments were conducted to demonstrate the use of passive samplers for soil vapor concentration monitoring. Five different passive samplers were studied (Radiello, SKC Ultra, Waterloo Membrane ...
The advent of next generation sequencing has led to an explosion of the amount of DNA sequences in public databases. A challenge is now to find tools that are able to make it easier for researchers to browse and make sense ...
In England, Dispensing Practices face the difficulty of purchasing drugs based on clinical
need but must strike a balance of retaining cost effectiveness, provide value for money
whilst simultaneously maximising profits. ...
Prostate carcinoma is a fatal malignancy and is a major cause of death in men in the
population aged 55 and over. Early diagnosis of prostate cancer is very important for
successful treatment of the disease. The increase ...
This study investigated the effects of interacting environmental factors on the
ecophysiology of Aspergillus carbonarius and ochratoxin A (OTA) production, to
facilitate the building of a database of knowledge for risk ...
The aim of the work described in this thesis was to develop novel methods for the
extraction of gene regulatory networks (GRN) from gene expression data, and use these
methods to capture previously unknown relationships ...
Gastrointestinal symptoms have been observed to be present very often in autistic children.
These symptoms are very similar to those observed in Irritable Bowel Syndrome (IBS). An
investigation to investigate whether ...
The thesis describes the development of generic platforms for labeless transduction of
binding events. A particular application of the project is the labeless detection of
biochemical markers for stroke, specifically ...
The UK Strategic Defence and Security Review (2015), places ‘cyber’ in the highest category tier-one risk. The threats from cyberspace is ever increasing as UK Armed Forces is becoming increasingly dependent on its’ ...
A Hydraulic Lung has been designed and constructed. The Hydraulic Lung can inhale
through a Dry Powder Inhaler (DPI) with a pre-determined level of inspiratory effort,
and the characteristics of the inhalation profile ...
Due to an aging population and younger patients presenting with musculoskeletal disorders, there is a need for orthopaedic implants with improved healing rates and longer implant life. Numerous research has developed implant ...
Introduction
A biosensor may be described as a sensor incorporating a biological element such as an enzyme, antibody, nucleic acid, microorganism or cell. A biosensor should exhibit both shelf-stability and operation ...
Irfan, Muhammad Adeel(Cranfield University, 2013-11)
The rapid development of nanotechnology has caused concerns about
nanoproducts on human health throughout their lifecycle. As part of the consortium
NEPHH (nanomaterial related environmental pollution on human health ...
Phenolic and antioxidant contents of wines are very important in terms of both flavour attributes
and health benefits. Changes occur during ageing of wine in containers (e.g. wooden barrels) in
relation to their antioxidant ...
De Sousa, C. A. Ferreira(Cranfield University, 2013-09)
The segmentation of the axial skeleton and peripheral nervous system involves a complex integration of multiple patterning molecules. For the latter, axon-repelling molecules in the posterior half-sclerotome are particularly ...