Revisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor

Date published

2022-07-18

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American Chemical Society

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Article

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0888-5885

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Cox R, Salonitis K, Rebrov E, Impey SA. (2022) Revisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor. Industrial and Engineering Chemistry Research, Volume 61, Issue 30, 3 August 2022, pp. 11181–11196

Abstract

Abstract

An oscillatory baffled flow reactor (OBR) has been designed with 60 interbaffled cells. The baffled columns of 40 mm internal diameter together result in a reactor length of 5740 mm. The oscillatory amplitude and frequency were in the range of 2–12 mm and 0.3–2 Hz, respectively. The report investigates the impact of U-bends and the number of reactor sections on axial dispersion for scale-up feasibility. A prediction model using operating parameters has been developed to maximize plug flow conditions using the tanks-in-series (TiS) model. The maximum TiS value was 13.38 in a single column compared to 43.68 in the full reactor at a velocity ratio of 2.27 using oscillatory parameters 8 mm and 0.3 Hz. The mixing efficiency along the reactor was found to decrease after each column at amplitudes <6 mm compared to amplitudes up to 12 mm, where a negligible impact was observed. U-bend geometry had a significant role in the decrease of TiS values.

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Github

Keywords

Oscillatory Baffled Flow Reactor, Tanks-in-Series, Velocity Ratio, Scale-Up Feasibility, U-Bends

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Attribution 4.0 International

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