Age related changes of rib cortical bone matrix and the application to forensicage-at-death estimation

Show simple item record Bonicelli, Andrea Zioupos, Peter Arnold, Emily Rogers, Keith D. Xhemali, Bledar Kranioti, Elena F. 2021-02-08T14:33:02Z 2021-02-08T14:33:02Z 2021-01-22
dc.identifier.citation Bonicelli A, Zioupos P, Arnold E, et al. (2021) Age related changes of rib cortical bone matrix and the application to forensic age-at-death estimation. Scientific Reports, Volume 11, Article number 2086 en_UK
dc.identifier.issn 2045-2322
dc.description.abstract Forensic anthropology includes, amongst other applications, the positive identification of unknown human skeletal remains. The first step in this process is an assessment of the biological profile, that is: sex, age, stature and ancestry. In forensic contexts, age estimation is one of the main challenges in the process of identification. Recently established admissibility criteria are driving researchers towards standardisation of methodological procedures. Despite these changes, experience still plays a central role in anthropological examinations. In order to avoid this issue, age estimation procedures (i) must be presented to the scientific community and published in peer reviewed journals, (ii) accurately explained in terms of procedure and (iii) present clear information about the accuracy of the estimation and possible error rates. In order to fulfil all these requirements, a number of methods based on physiological processes which result in biochemical changes in various tissue structures at the molecular level, such as modifications in DNA-methylation and telomere shortening, racemization of proteins and stable isotopes analysis, have been developed. The current work proposes a new systematic approach in age estimation based on tracing physicochemical and mechanical degeneration of the rib cortical bone matrix. This study used autopsy material from 113 rib specimens. A set of 33 parameters were measured by standard bio-mechanical (nanoindentation and microindentation), physical (TGA/DSC, XRD and FTIR) and histomorphometry (porosity-ImageJ) methods. Stepwise regressions were used to create equations that would produce the best ‘estimates of age at death’ vs real age of the cadavers. Five equations were produced; in the best of cases an equation counting 7 parameters had an R2 = 0.863 and mean absolute error of 4.64 years. The present method meets all the admissibility criteria previously described. Furthermore, the method is experience-independent and as such can be performed without previous expert knowledge of forensic anthropology and human anatomy. en_UK
dc.language.iso en en_UK
dc.publisher Nature Publishing Group en_UK
dc.rights Attribution 4.0 International *
dc.rights.uri *
dc.title Age related changes of rib cortical bone matrix and the application to forensicage-at-death estimation en_UK
dc.type Article en_UK

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