Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site

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dc.contributor.author Mehta, Neha
dc.contributor.author Cipullo, Sabrina
dc.contributor.author Cocerva, Tatiana
dc.contributor.author Coulon, Frederic
dc.contributor.author Dino, Giovanna Antonella
dc.contributor.author Ajmone-Marsan, Franco
dc.contributor.author Padoan, Elio
dc.contributor.author Cox, Siobhan Fiona
dc.contributor.author Cave, Mark R.
dc.contributor.author De Luca, Domenico Antonio
dc.date.accessioned 2020-04-30T14:20:43Z
dc.date.available 2020-04-30T14:20:43Z
dc.date.issued 2020-04-30
dc.identifier.citation Mehta N, Cipullo S, Cocerva T, et al., (2020) Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site. Chemosphere, Available online 30 April 2020, Article number 126927 en_UK
dc.identifier.issn 0045-6535
dc.identifier.uri https://doi.org/10.1016/j.chemosphere.2020.126927
dc.identifier.uri http://dspace.lib.cranfield.ac.uk/handle/1826/15421
dc.description.abstract The waste rock, tailings and soil around an abandoned mine site in Gorno (northwest Italy) contain elevated concentrations of potentially toxic elements (PTE) exceeding the permissible limits for residential uses. Specifically, the maximum concentrations of As, Cd, Pb, and Zn were 107 mg/kg, 340 mg/kg, 1064 mg/kg, and 148 433 mg/kg, respectively. A site-specific human health risk assessment (HHRA) was conducted for residential and recreational exposure scenarios, using an approach based on Risk Based Corrective Action (RBCA) method, refined by incorporating oral bioaccessibility data. Oral bioaccessibility analyses were performed by simulating the human digestion process in vitro (Unified BARGE Method). Detailed analysis of oral bioaccessible fraction (BAF i.e. ratio of bioaccessible concentrations to total concentrations on <250 μm fraction) indicated BAF of As (5-33%), Cd (72-98%), Co (24-42%), Cr (3-11%), Cu (25-90%), Ni (17-60%), Pb (16-88%) and Zn (73-94%). The solid phase distribution and mineralogical analyses showed that the variation of BAF is attributed to presence of alkaline calcareous rocks and association of PTE with a variety of minerals. The HHRA for ingestion pathway, suggested that bioaccessibility-corrected cancer risk reached up to 2.7 × 10−5 and 0.55 × 10−5 for residential and recreational senarios respectively (acceptable level is 1 × 10−5). The hazard index (HI) recalculated after incorporation of oral bioaccessible concentrations for a residential scenario ranged from 0.02 to 17.9. This was above the acceptable level (>1) for 50% of the samples, indicating potential human health risks. This study provides information for site-specific risk assessments and planning future research. en_UK
dc.language.iso en en_UK
dc.publisher Elsevier en_UK
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Abandoned mine site en_UK
dc.subject Bioaccessibility en_UK
dc.subject Risk assessment en_UK
dc.subject Solid phase distribution en_UK
dc.subject Potentially toxic elements (PTE) en_UK
dc.subject Triassic western southern Alps (Italy) en_UK
dc.title Incorporating oral bioaccessibility into human health risk assessment due to potentially toxic elements in extractive waste and contaminated soils from an abandoned mine site en_UK
dc.type Article en_UK


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