Molecularly imprinted nanoparticles based sensor for cocaine detection

Show simple item record D’Aurelio, Roberta Chianella, Iva Goode, Jack A. Tothill, Ibtisam E. 2020-03-25T16:41:54Z 2020-03-25T16:41:54Z 2020-03-04
dc.identifier.citation D’Aurelio R, Chianella I, Goode JA, et al., (2020) Molecularly imprinted nanoparticles based sensor for cocaine detection. Biosensors, Volume 10, Issue 3, 2020, Article number 22 en_UK
dc.identifier.issn 2079-6374
dc.description.abstract The development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as the sensing element. The nanoMIPs were first characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering and found to be ~148.35 ± 24.69 nm in size, using TEM. The nanoMIPs were then covalently attached to gold screen-printed electrodes and a cocaine direct binding assay was developed and optimized, using EIS as the sensing principle. EIS was recorded at a potential of 0.12 V over the frequency range from 0.1 Hz to 50 kHz, with a modulation voltage of 10 mV. The nanoMIPs sensor was able to detect cocaine in a linear range between 100 pg mL−1 and 50 ng mL−1 (R2 = 0.984; p-value = 0.00001) and with a limit of detection of 0.24 ng mL−1 (0.70 nM). The sensor showed no cross-reactivity toward morphine and a negligible response toward levamisole after optimizing the sensor surface blocking and assay conditions. The developed sensor has the potential to offer a highly sensitive, portable and cost-effective method for cocaine detection. en_UK
dc.language.iso en en_UK
dc.publisher MDPI en_UK
dc.rights Attribution 4.0 International *
dc.rights.uri *
dc.subject Cocaine en_UK
dc.subject Drugs of abuse en_UK
dc.subject Electrochemical impedance spectroscopy en_UK
dc.subject molecularly imprinted polymer nanoparticles en_UK
dc.subject EIS sensor en_UK
dc.title Molecularly imprinted nanoparticles based sensor for cocaine detection en_UK
dc.type Article en_UK

Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International Except where otherwise noted, this item's license is described as Attribution 4.0 International

Search CERES


My Account