Molecularly imprinted nanoparticles based sensor for cocaine detection

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dc.contributor.author D’Aurelio, Roberta
dc.contributor.author Chianella, Iva
dc.contributor.author Goode, Jack A.
dc.contributor.author Tothill, Ibtisam E.
dc.date.accessioned 2020-03-25T16:41:54Z
dc.date.available 2020-03-25T16:41:54Z
dc.date.issued 2020-03-04
dc.identifier.citation D’Aurelio R, Chianella I, Goode JA, et al., (2020) Molecularly imprinted nanoparticles based sensor for cocaine detection. Biosensors, Volume 10, Issue 3, 2020, Article number 22 en_UK
dc.identifier.issn 2079-6374
dc.identifier.uri https://doi.org/10.3390/bios10030022
dc.identifier.uri http://dspace.lib.cranfield.ac.uk/handle/1826/15326
dc.description.abstract The development of a sensor based on molecularly imprinted polymer nanoparticles (nanoMIPs) and electrochemical impedance spectroscopy (EIS) for the detection of trace levels of cocaine is described in this paper. NanoMIPs for cocaine detection, synthesized using a solid phase, were applied as the sensing element. The nanoMIPs were first characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering and found to be ~148.35 ± 24.69 nm in size, using TEM. The nanoMIPs were then covalently attached to gold screen-printed electrodes and a cocaine direct binding assay was developed and optimized, using EIS as the sensing principle. EIS was recorded at a potential of 0.12 V over the frequency range from 0.1 Hz to 50 kHz, with a modulation voltage of 10 mV. The nanoMIPs sensor was able to detect cocaine in a linear range between 100 pg mL−1 and 50 ng mL−1 (R2 = 0.984; p-value = 0.00001) and with a limit of detection of 0.24 ng mL−1 (0.70 nM). The sensor showed no cross-reactivity toward morphine and a negligible response toward levamisole after optimizing the sensor surface blocking and assay conditions. The developed sensor has the potential to offer a highly sensitive, portable and cost-effective method for cocaine detection. en_UK
dc.language.iso en en_UK
dc.publisher MDPI en_UK
dc.rights Attribution 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ *
dc.subject Cocaine en_UK
dc.subject Drugs of abuse en_UK
dc.subject Electrochemical impedance spectroscopy en_UK
dc.subject molecularly imprinted polymer nanoparticles en_UK
dc.subject EIS sensor en_UK
dc.title Molecularly imprinted nanoparticles based sensor for cocaine detection en_UK
dc.type Article en_UK


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