Age-related changes in femoral head trabecular microarchitecture

Show simple item record Greenwood, Charlene Clement, John Dicken, Anthony Evans, Paul Lyburn, Iain Douglas Martin, Richard M. Stone, Nick Zioupos, Peter Rogers, Keith 2018-10-08T13:57:49Z 2018-10-08T13:57:49Z 2017-10-11
dc.identifier.citation Greenwood C, Clement J, Dicken A. (2018) Age-related changes in femoral head trabecular microarchitecture. Aging and Disease, Volume 9, Issue 6, December 2018, pp.976-987 en_UK
dc.identifier.issn 2152-5250
dc.description.abstract Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of bone mineral density using dual energy X-ray absorption. However, many studies have shown that bone strength, and consequently the probability of fracture, is a combination of both bone mass and bone ‘quality’ (architecture and material chemistry). Although the microarchitecture of both non-fracture and osteoporotic bone has been previously investigated, many of the osteoporotic studies are constrained by factors such as limited sample number, use of ovariectomised animal models, and lack of male and female discrimination. This study reports significant differences in bone quality with respect to the microarchitecture between fractured and non-fractured human femur specimens. Micro-computed tomography was utilised to investigate the microarchitecture of femoral head trabecular bone from a relatively large cohort of non-fracture and fracture human donors. Various microarchitectural parameters have been determined for both groups, providing an understanding of the differences between fracture and non -fracture material. The microarchitecture of non-fracture and fracture bone tissue is shown to be significantly different for many parameters. Differences between sexes also exist, suggesting differences in remodelling between males and females in the fracture group. The results from this study will, in the future, be applied to develop a fracture model which encompasses bone density, architecture and material chemical properties for both female and male tissues. en_UK
dc.language.iso en en_UK
dc.publisher Buck Institute for Age Research en_UK
dc.rights Attribution 4.0 International *
dc.rights.uri *
dc.subject micro computed tomography (μ-CT) en_UK
dc.subject osteoporosis en_UK
dc.subject aging en_UK
dc.subject microarchitecture en_UK
dc.subject trabecular bone en_UK
dc.subject femoral head en_UK
dc.title Age-related changes in femoral head trabecular microarchitecture en_UK
dc.type Article en_UK
dc.identifier.cris 19958671

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