Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process

Date published

2017-12-12

Free to read from

Supervisor/s

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Department

Type

Article

ISSN

0896-8446

Format

Citation

Ravenna Lessa Matos, Tiejun Lu, Christopher McConville, et al., Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process, Journal of Supercritical Fluids, Volume 141, November 2018, Pages 143-156

Abstract

Dry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.

Description

Software Description

Software Language

Github

Keywords

Supercritical antisolvent, Fluidized bed, Coating, Curcumin, Lactose, Pulmonary delivery

DOI

Rights

Attribution-NonCommercial-NoDerivatives 4.0 International

Relationships

Relationships

Supplements

Funder/s