Encapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrier

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dc.contributor.author Almoussalam, Musallam
dc.contributor.author Zhu, Huijin
dc.date.accessioned 2016-08-11T18:42:47Z
dc.date.available 2016-08-11T18:42:47Z
dc.date.issued 2016-04-26
dc.identifier.citation Almoussalam, M, Zhu, H. (2016) Encapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrier, 110, e53760 en_UK
dc.identifier.issn 1940-087X
dc.identifier.uri http://dx.doi.org/10.3791/53760
dc.identifier.uri http://dspace.lib.cranfield.ac.uk/handle/1826/10282
dc.description.abstract The only formula of dacarbazine (Dac) in clinical use is intravenous infusion, presenting a poor therapeutic profile due to the low dispersity of the drug in aqueous solution To overcome this, a nanostructured lipid carrier (NLC) consisting of glyceryl palmitostearate and isopropyl myristate was developed to encapsulate Dac. NLCs with controlled size were achieved using high shear dispersion (HSD) following solidification of oil-in-water emulsion. The synthesis parameters, including surfactant concentration, the speed and time of HSD were optimized to achieve the smallest NLC with size, polydispersion index and zeta potential of 155 ± 10 nm, 0.2 ± 0.01, and -43.4 ± 2 mV, respectively. The optimal parameters were also employed for Dac-loaded NLC preparation. The resultant NLC loaded with Dac possessed size, polydispersion index and zeta potential of 190 ± 10 nm, 0.2 ± 0.01, and -43.5 ± 1.2 mV, respectively. The drug encapsulation efficiency and drug loading reached 98% and 14%, respectively. This is the first report on encapsulation of Dac using NLC, implying that NLC could be a new potential candidate as drug carrier to improve the therapeutic profile of Dac. en_UK
dc.language.iso en en_UK
dc.publisher JOVE en_UK
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Nanostructured lipid carrier en_UK
dc.subject NLC en_UK
dc.subject Dacarbazine en_UK
dc.subject DAC en_UK
dc.subject High shear dispersion en_UK
dc.subject HSD en_UK
dc.subject Drug delivery en_UK
dc.title Encapsulation of cancer therapeutic agent dacarbazine using nanostructured lipid carrier en_UK
dc.type Article en_UK


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