Browsing by Author "Lyburn, Iain Douglas"

Browsing by Author "Lyburn, Iain Douglas"

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  • Age-related changes in femoral head trabecular microarchitecture 
    Greenwood, Charlene; Clement, John; Dicken, Anthony; Evans, Paul; Lyburn, Iain Douglas; Martin, Richard M.; Stone, Nick; Zioupos, Peter; Rogers, Keith (Buck Institute for Age Research, 2017-10-11)
    Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification ...
  • Calcification microstructure reflects breast tissue microenvironment 
    Gosling, Sarah; Scott, Robert; Greenwood, Charlene; Bouzy, Pascaline; Nallala, Jayakrupakar; Lyburn, Iain Douglas; Stone, Nicholas; Rogers, Keith (Springer, 2019-12-05)
    Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. ...
  • Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter 
    Dicken, A. J.; Evans, J. Paul O.; Rogers, Keith; Stone, N.; Greenwood, Charlene; Godber, S. X.; Clement, J. G.; Lyburn, Iain Douglas; Martin, R. M.; Zioupos, Peter (Nature Publishing Group, 2016-07-01)
    Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and ...
  • Developing focal construct technology for in vivo diagnosis of osteoporosis 
    Greenwood, Charlene; Rogers, Keith; Wilson, M.; Lyburn, Iain Douglas; Evans, P.; Prokopiou, Danae (IOP, 2019-03-18)
    Osteoporosis is a prevalent bone disease around the world, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is ...
  • Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer 
    Bouzy, Pascaline; Lyburn, Iain Douglas; Pinder, Sarah E.; Scott, Robert; Mansfield, Jessica; Moger, Julian; Greenwood, Charlene; Bouybayoune, Ihssane; Cornford, Eleanor; Rogers, Keith; Stone, Nick (Royal Society of Chemistry, 2023-02-21)
    Microcalcifications play an important role in cancer detection. They are evaluated by their radiological and histological characteristics but it is challenging to find a link between their morphology, their composition and ...
  • Fracture toughness of the cancellous bone of FNF femoral heads in relation to its microarchitecture 
    Greenwood, Charlene; Clements, J. G.; Dicken, A. J.; Evans, J. Paul O.; Lyburn, Iain Douglas; Martin, R. M.; Rogers, Keith; Stone, N.; Adams, G.; Zioupos, Peter (European Society of Biomechanics, 2016-07)
    This study considers the relationship between microarchitecture and mechanical properties for cancellous bone specimens collected from a cohort of patients who had suffered fractured necks of femur. OP is an acute skeletal ...
  • The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue 
    Greenwood, Charlene; Clement, J. G.; Dicken, A. J.; Evand, J. P. O.; Lyburn, Iain Douglas; Martin, R. M.; Rogers, Keith; Stone, N.; Adams, G.; Zioupos, Peter (Elsevier, 2015-10-05)
    Osteoporosis is clinically assessed from bone mineral density measurements using dual energy X-ray absorption (DXA). However, these measurements do not always provide an accurate fracture prediction, arguably because DXA ...
  • A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications 
    Gosling, Sarah; Calabrese, Doriana; Nallala, Jayakrupakar; Greenwood, Charlene; Pinder, Sarah; King, Lorraine; Marks, Jeffrey; Pinto, Donna; Lynch, Thomas; Lyburn, Iain Douglas; Hwang, Shelley; Grand Challenge PRECISION Consortium; Rogers, Keith; Stone, Nicholas (Royal Society of Chemistry, 2022-03-21)
    Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray ...
  • Towards new material biomarkers for fracture risk 
    Greenwood, Charlene; Clement, J.; Dicken, Anthony; Evans, J.; Lyburn, Iain Douglas; Martin, R.; Rogers, Keith; Stone, N.; Zioupos, Peter (2016-09-30)
    Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of ...