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Browsing by Author "Greenwood, Charlene"

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Age-related changes in femoral head trabecular microarchitecture

Greenwood, Charlene; Clement, John; Dicken, Anthony; Evans, Paul; Lyburn, Iain Douglas; Martin, Richard M.; Stone, Nick; Zioupos, Peter; Rogers, Keith (Buck Institute for Age Research, 2017-10-11)

Osteoporosis is a prevalent bone condition, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification ...
Age-related trends in the trabecular micro-architecture of the medial clavicle: is it of use in forensic science?

McGivern, Hannah; Greenwood, Charlene; Márquez-Grant, Nicholas; Kranioti, Elena F.; Xhemali, Bledar; Zioupos, Peter (Frontiers, 2020-01-22)

The mechanical and structural properties of bone are known to change significantly with age. Within forensic and archaeological investigations, the medial end of the clavicle is typically used for estimating the age-at-death ...
Breast calcification micromorphology classification

Robert Scott, Robert Scott; Iain Lyburn, Iain Lyburn; Cornford, Eleanor; Bouzy, Pascaline; Stone, Nicholas; Greenwood, Charlene; Bouybayoune, Ihsanne; Pinder, Sarah; Rogers, Keith (British Institute of Radiology, 2022-07-25)

Objectives: The importance of consistent terminology in describing the appearance of breast calcifications in mammography is well recognised. Imaging of calcifications using electron microscopy is a globally growing ...
Calcification microstructure reflects breast tissue microenvironment

Gosling, Sarah; Scott, Robert; Greenwood, Charlene; Bouzy, Pascaline; Nallala, Jayakrupakar; Lyburn, Iain Douglas; Stone, Nicholas; Rogers, Keith (Springer, 2019-12-05)

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. ...
Classification of fracture and non-fracture groups by analysis of coherent X-ray scatter

Dicken, A. J.; Evans, J. Paul O.; Rogers, Keith; Stone, N.; Greenwood, Charlene; Godber, S. X.; Clement, J. G.; Lyburn, Iain Douglas; Martin, R. M.; Zioupos, Peter (Nature Publishing Group, 2016-07-01)

Osteoporotic fractures present a significant social and economic burden, which is set to rise commensurately with the aging population. Greater understanding of the physicochemical differences between osteoporotic and ...
Conical shell X-ray beam tomosynthesis and micro-computed tomography for microarchitectural characterisation

Arnold, Emily; Elarnaut, Farid; Downes, David; Evans, J. Paul O.; Greenwood, Charlene; Rogers, Keith D. (Springer Nature, 2023-12-06)

Bone quality is commonly used to diagnose bone diseases such as osteoporosis, with many studies focusing on microarchitecture for fracture prediction. In this study a bovine distal femur was imaged using both micro-computed ...
Developing focal construct technology for in vivo diagnosis of osteoporosis

Greenwood, Charlene; Rogers, Keith; Wilson, M.; Lyburn, Iain Douglas; Evans, P.; Prokopiou, Danae (IOP, 2019-03-18)

Osteoporosis is a prevalent bone disease around the world, characterised by low bone mineral density and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is ...
Establishing a minimum PMI for bone sun bleaching in a UK environment with a controlled desert-simulated comparison

Stokes, Sarah; Márquez-Grant, Nicholas; Greenwood, Charlene (Springer, 2020-08-15)

Microenvironments play a significant part in understanding the post-mortem interval in forensic taphonomy. Recently, the value of weathering factors in relation to obtaining a PMI has been investigated further. In this ...
Exploration of utility of combined optical photothermal infrared and Raman imaging for investigating the chemical composition of microcalcifications in breast cancer

Bouzy, Pascaline; Lyburn, Iain Douglas; Pinder, Sarah E.; Scott, Robert; Mansfield, Jessica; Moger, Julian; Greenwood, Charlene; Bouybayoune, Ihssane; Cornford, Eleanor; Rogers, Keith; Stone, Nick (Royal Society of Chemistry, 2023-02-21)

Microcalcifications play an important role in cancer detection. They are evaluated by their radiological and histological characteristics but it is challenging to find a link between their morphology, their composition and ...
Fracture toughness of the cancellous bone of FNF femoral heads in relation to its microarchitecture

Greenwood, Charlene; Clements, J. G.; Dicken, A. J.; Evans, J. Paul O.; Lyburn, Iain Douglas; Martin, R. M.; Rogers, Keith; Stone, N.; Adams, G.; Zioupos, Peter (European Society of Biomechanics, 2016-07)

This study considers the relationship between microarchitecture and mechanical properties for cancellous bone specimens collected from a cohort of patients who had suffered fractured necks of femur. OP is an acute skeletal ...
Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite

Arnold, Emily; Keeble, Dean S.; Evans, J. Paul O.; Greenwood, Charlene; Rogers, Keith D. (International Union of Crystallography, 2022-04-14)

Hydroxyapatite (HA) is a complex material, which is often nanocrystalline when found within a biological setting. This work has directly compared the structural characteristics derived from data collected using a ...
The micro-architecture of human cancellous bone from fracture neck of femur patients in relation to the structural integrity and fracture toughness of the tissue

Greenwood, Charlene; Clement, J. G.; Dicken, A. J.; Evand, J. P. O.; Lyburn, Iain Douglas; Martin, R. M.; Rogers, Keith; Stone, N.; Adams, G.; Zioupos, Peter (Elsevier, 2015-10-05)

Osteoporosis is clinically assessed from bone mineral density measurements using dual energy X-ray absorption (DXA). However, these measurements do not always provide an accurate fracture prediction, arguably because DXA ...
A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications

Gosling, Sarah; Calabrese, Doriana; Nallala, Jayakrupakar; Greenwood, Charlene; Pinder, Sarah; King, Lorraine; Marks, Jeffrey; Pinto, Donna; Lynch, Thomas; Lyburn, Iain Douglas; Hwang, Shelley; Grand Challenge PRECISION Consortium; Rogers, Keith; Stone, Nicholas (Royal Society of Chemistry, 2022-03-21)

Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray ...
New insights into the application of pair distribution function studies to biogenic and synthetic hydroxyapatites

Arnold, Emily; Keeble, Dean S.; Greenwood, Charlene; Rogers, Keith D. (Springer, 2020-11-11)

Biogenic and synthetic hydroxyapatites are confounding materials whose properties remain uncertain, even after years of study. Pair distribution function (PDF) analysis was applied to hydroxyapatites in the 1970’s and ...
Physiochemical modifications to bone mineral

Greenwood, Charlene (2016-10-05)

Bone is a complex composite material consisting of three main components: a mineral phase structurally similar to calcium hydroxyapatite (HAp), an organic matrix containing collagenous and non-collagenous proteins and, ...
A pilot study: effect of irisin on trabecular bone in a streptozotocin-induced animal model of type 1 diabetic osteopathy utilizing a micro-CT

Mohsin, Sahar; Brock, Fiona; Kaimala, Suneesh; Greenwood, Charlene; Sulaiman, Mohsin; Rogers, Keith; Adeghate, Ernest (PeerJ Publishing, 2023-10-17)

Background. Osteoporosis is a significant co-morbidity of type 1 diabetes mellitus (DM1) 41 leading to increased fracture risk. Exercise-induced hormone 'irisin' in low dosage has been 42 shown to have a beneficial effect ...
Thermally dynamic examination of local order in nanocrystalline hydroxyapatite

Arnold, Emily; Gosling, Sarah; Davies, Samantha K.; Cross, Hannah L.; Evans, Paul; Keeble, Dean S.; Greenwood, Charlene; Rogers, Keith D. (Elsevier, 2022-08-13)

The main mineral component of bone is hydroxyapatite, a commonly nanocrystalline material which presents many challenges for those trying to characterize it. Here, local structure is analyzed using X-ray total scattering ...
Towards new material biomarkers for fracture risk

Greenwood, Charlene; Clement, J.; Dicken, Anthony; Evans, J.; Lyburn, Iain Douglas; Martin, R.; Rogers, Keith; Stone, N.; Zioupos, Peter (2016-09-30)

Osteoporosis is a prevalent bone condition, characterised by low bone mass and increased fracture risk. Currently, the gold standard for identifying osteoporosis and increased fracture risk is through quantification of ...
Translating microcalcification biomarker information into the laboratory: a preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification

Lyburn, Iain D.; Scott, Robert; Cornford, Eleanor; Bouzy, Pascaline; Stone, Nicholas; Greenwood, Charlene; Bouybayoune, Ihsanne; Pinder, Sarah E.; Rogers, Keith (Elsevier, 2024-03-12)

The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to date, been limited to high brightness, ...
The use of μCT and fractal dimension for fracture prediction in osteoporotic individuals

Arnold, Emily; Clement, John; Rogers, Keith D.; Garcia-Castro, Fabio; Greenwood, Charlene (Elsevier, 2019-12-11)

Osteoporosis (OP) is a widespread condition with commonly associated fracture sites at the hip, vertebra and wrist. This study examines the effects of age and osteoporosis on bone quality by comparing the efficacy of using ...

Browsing by Author "Greenwood, Charlene"

Browsing by Author "Greenwood, Charlene"

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